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General Information
ZIRC
ZFIN ID: ZDB-GENE-051012-1
Gene Name: BCL2 apoptosis regulator a
Gene Symbol: bcl2a    Nomenclature History

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Previous Names: bcl2, zBlp2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to the mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Orthologous to human BCL2 (BCL2 apoptosis regulator).
Genome Resources: Alliance (1),  Gene:570772 (1),  Ensembl(GRCz11):ENSDARG00000094704 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bcl2a N/A 1
MO2-bcl2a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH bcl2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia/lymphoma, B-cell, 2
DISEASE ASSOCIATED WITH bcl2a VIA EXPERIMENTAL MODELS No data available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA bcl2a-201 (1)    Ensembl 1828
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM bcl2a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Gt(bcl2a-EGFP) bcl2aEGFP Danio rerio 5 11
Gt2(bcl2a-EGFP) bcl2aEGFP Danio rerio 3 9
Tg(myo6b:EGFP-bcl2a,myl7:EGFP) myl7myo6b bcl2aEGFP Danio rerio 1 3
Tg(rag2:EGFP-bcl2a) rag2 bcl2aEGFP Danio rerio 1 12
Tg(rag2:mCherry-bcl2a) rag2 bcl2amCherry Danio rerio 1 1
Tg(Xla.Tubb2b:bcl2a) bcl2a Danio rerioXenopus laevis 1 2
MARKER RELATIONSHIPS
bcl2a Contained in: [BAC] CH73-74B21 (1) (order this), CH211-121F17 (1) (order this)
bcl2a Encodes: [cDNA] MGC:162054 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001030253 (1) 1150 bp
Genomic GenBank:CU695001 (1) 98270 bp
Select Tool
Polypeptide UniProtKB:Q564A4 (1) 228 aa
Sequence Clusters UniGene:45607 (1)
Sequence Information (all 16)
ORTHOLOGY for bcl2a ( Chr: 24 )
CITATIONS (195)