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Gene

bcl2l1

ID
ZDB-GENE-010730-1
Name
BCL2 like 1
Symbol
bcl2l1 Nomenclature History
Previous Names
  • bcl-XL (1)
  • bcl2l
  • cb1021 (1)
  • zfBLP1 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Acts upstream of or within negative regulation of apoptotic process; thyroid gland development; and tissue homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Porreca et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bcl2l1 Human Ortholog
No data available
Associated With bcl2l1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Domain IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
Family IPR002475 Bcl2-like
Family IPR013279 Apoptosis regulator, Bcl-X
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Apoptosis regulator, Bcl-2, BH1 motif, conserved site Apoptosis regulator, Bcl-2 protein, BH4 Apoptosis regulator, Bcl-X Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:Q90Z98 238
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations