ZFIN ID: ZDB-GENE-010730-1
Gene Name: BCL2 like 1
Gene Symbol: bcl2l1    Nomenclature History

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Previous Names: bcl-XL (1), bcl2l, cb1021 (1), zfBLP1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of apoptotic process; thyroid gland development; and tissue homeostasis. Predicted to localize to mitochondrial outer membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).
Genome Resources: Alliance (1),  Gene:114401 (1),  Ensembl(GRCz11):ENSDARG00000008434 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010762Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15253 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bcl2l1 N/A 2
    MO2-bcl2l1 N/A 1
    DISEASE ASSOCIATED WITH bcl2l1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bcl2l1 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bcl2l1-201 (1)    Ensembl 2025
    bcl2l1-202 (1)    Ensembl 1979
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bcl2l1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rag2:EGFP-bcl2l1) rag2 bcl2l1EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    bcl2l1 Contained in: [BAC] DKEY-192I18 (1) (order this)
    bcl2l1 Encodes: [EST] cb1021 (1) (order this), IMAGE:6910760 (1)
    [cDNA] MGC:55232 (1), MGC:86578 (1), MGC:192331 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131807 (1) 1942 nt
    Genomic GenBank:CR788311 (1) 147664 nt
    Select Tool
    Polypeptide UniProtKB:Q90Z98 (1) 238 aa
    Sequence Information (all 23)
    ORTHOLOGY for bcl2l1 ( Chr: 23 )
    CITATIONS (82)