ZFIN ID: ZDB-GENE-020829-1
Gene Name: SIM bHLH transcription factor 1a
Gene Symbol: sim1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: sim1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in nervous system development and proximal tubule development. Predicted to localize to nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; corpuscles of Stannius; intermediate mesoderm; and pronephros. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
Genome Resources: Alliance (1),  Gene:260351 (1),  Ensembl(GRCz11):ENSDARG00000023316 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2864 Point Mutation Unknown Splice Site ENU
sa30996 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36012 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42640 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42641 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sim1a N/A 7
    MO2-sim1a N/A 5
    MO3-sim1a N/A 1
    MO4-sim1a N/A 1
    DISEASE ASSOCIATED WITH sim1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sim1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sim1a-201 (1)    Ensembl 2655
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sim1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:sim1a,LY-Tomato) hsp70l LYsim1aTomato Danio rerio 1 2
    MARKER RELATIONSHIPS
    sim1a Contained in: [BAC] CH211-167H2 (1), DKEY-265C18 (1) (order this)
    sim1a Encodes: [EST] ay028626
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178222 (1) 2664 nt
    Genomic GenBank:BX005277 (1) 137475 nt
    Select Tool
    Polypeptide UniProtKB:F1QMF7 (1) 745 aa
    Sequence Information (all 12)
    ORTHOLOGY for sim1a ( Chr: 16 )
    CITATIONS (49)