ZFIN ID: ZDB-GENE-980526-212
Gene Name: distal-less homeobox 2a
Gene Symbol: dlx2a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: dlx-2, dlx2, zgc:110518

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to localize to the nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2).
Genome Resources: Alliance (1),  Gene:30574 (1),  Ensembl(GRCz11):ENSDARG00000079964 (2)
GENE EXPRESSION
All Expression Data: 375 figures from 258 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu96]
  12 figures (14 images) from Rauch et al., 2003 [fc28e03]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11175 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlx2a N/A 3
    MO2-dlx2a N/A 3
    DISEASE ASSOCIATED WITH dlx2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dlx2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000047 Helix-turn-helix motif
    Domain IPR001356 Homeobox domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR020479 Homeobox domain, metazoa
    Domain IPR022135 Distal-less-like homeobox protein, N-terminal domain
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(dlx1aIG:GFP) dlx1adlx2a GFP Danio rerio 2 4
    Tg(dlx1aURE2:GFP) dlx1adlx2a GFP Danio rerio 2 5
    MARKER RELATIONSHIPS
    dlx2a Contained in: [BAC] CH211-245G15 (1)
    dlx2a Encodes: [EST] eu96 (1), fc28e03 (1) (order this)
    [cDNA] MGC:110518
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131311 (1) 1668 bp
    Genomic GenBank:BX248116 (1) 161065 bp
    Select Tool
    Polypeptide UniProtKB:F6NKE2 (1) 274 aa
    Sequence Clusters UniGene:2 (1)
    Sequence Information (all 18)
    ORTHOLOGY for dlx2a ( Chr: 9 )
    CITATIONS (397)