Fig. 5

Park et al., 2019 - 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
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Fig. 5

Sphk2 deletion suppresses liver defects in the kdsrI105R mutant. Images of live wild type (wt), kdsrI105R, and kdsrI105R; sphk2wc1 double mutant at 7 dpf (A). Scale bar = 0.25 mm. Relative mRNA expression of sphk2 and other genes associated with inflammation (tnfail1b), tissue injury (alpha1-anti-trypsin (a1at)) and fibrosis (col1a1a) (B), sphingolipid salvage pathway related genes (C) in wtkdsrI105Rsphk2wc1, and kdsrI105Rsphk2wc1 mutant siblings. spp1, (S1P-phosphohydrolase 1). Images of H&E and ORO staining in livers of wtkdsrI105R and kdsrI105Rsphk2wc1double mutants (D, n = 6). Error bars indicate standard deviation of the mean. *P ≤ 0.05, **P ≤ 0.005. Scale bare in D = 100 µm.

Expression Data
Anatomical Term:
Stage: Days 7-13

Expression Detail
Antibody Labeling
Phenotype Data
Observed In:
Stage: Days 7-13

Phenotype Detail
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