Gene

sgpl1

ID
ZDB-GENE-070410-24
Name
sphingosine-1-phosphate lyase 1
Symbol
sgpl1 Nomenclature History
Previous Names
  • spl (1)
  • zgc:162153
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have sphinganine-1-phosphate aldolase activity. Predicted to be involved in ameboidal-type cell migration and sphingolipid catabolic process. Predicted to localize to endoplasmic reticulum. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sgpl1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephrotic syndrome type 14 Alliance Nephrotic syndrome, type 14 617575
Associated With sgpl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:F1R912 306
UniProtKB:A0A2R8Q3N8 574
UniProtKB:A4QNU7 572
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations