Gene
sgpl1
- ID
- ZDB-GENE-070410-24
- Name
- sphingosine-1-phosphate lyase 1
- Symbol
- sgpl1 Nomenclature History
- Previous Names
-
- spl (1)
- zgc:162153
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have sphinganine-1-phosphate aldolase activity. Predicted to be involved in ameboidal-type cell migration and sphingolipid catabolic process. Predicted to localize to endoplasmic reticulum. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163588 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nephrotic syndrome type 14 | Alliance | Nephrotic syndrome, type 14 | 617575 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
Protein | Length | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
---|---|---|---|---|---|
UniProtKB:A4QNU7
|
572 | ||||
UniProtKB:F1R912
|
306 | ||||
UniProtKB:A0A2R8Q3N8
|
574 |
Interactions and Pathways
No data available
Plasmids
No data available