Gene

sgpl1

ID

ZDB-GENE-070410-24

Name

sphingosine-1-phosphate lyase 1

Symbol

sgpl1 Nomenclature History

Previous Names

spl (1)
zgc:162153

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable sphinganine-1-phosphate aldolase activity. Predicted to be involved in sphingolipid catabolic process. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7163588 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sgpl1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 14	Alliance	RENI syndrome	617575

Associated With sgpl1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002129	Pyridoxal phosphate-dependent decarboxylase
Family	IPR050477	Group II Amino Acid Decarboxylases
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Additional Resources	Length	Group II Amino Acid Decarboxylases	Pyridoxal phosphate-dependent decarboxylase	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase, major domain	Pyridoxal phosphate-dependent transferase, small domain
UniProtKB:A4QNU7	InterPro	572
UniProtKB:A0A2R8Q3N8	InterPro	574

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sgpl1-201 (1) Ensembl	Ensembl	3,460 nt	Select Tool ZFIN BLAST
mRNA	sgpl1-202 (1) Ensembl	Ensembl	917 nt	Select Tool ZFIN BLAST
mRNA	sgpl1-203 (1) Ensembl	Ensembl	5,652 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations