header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-1512
Gene Name: N-acylsphingosine amidohydrolase (acid ceramidase) 1b
Gene Symbol: asah1b
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:66026

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits N-acylsphingosine amidohydrolase activity. Involved in collateral sprouting. Predicted to localize to the lysosome. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis and  ...
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu946]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7165391]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19461 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko319a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH asah1b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Farber lipogranulomatosis Farber lipogranulomatosis 228000
    Spinal muscular atrophy with progressive myoclonic epilepsy 159950
    DISEASE ASSOCIATED WITH asah1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process self proteolysis (more)
    Cellular Component lysosome (more)
    Molecular Function ceramidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR016699 (1)
  • InterPro:IPR029130 (1)
  • InterPro:IPR029132 (1)
  • Pfam:PF02275 (1)
  • Pfam:PF15508 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA asah1b-002 (1) 538
    mRNA asah1b-201 (1) 1726
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM asah1b No data available
    MARKER RELATIONSHIPS
    asah1bContained in: [BAC] CH211-226M23 (order this), DKEYP-88C1 (1)
    asah1bEncodes: [EST] eu946 (1), IMAGE:7165391 (1) (order this)
    [cDNA] MGC:66026 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200577 (1) 1717bp
    Genomic GenBank:AL935291 (1) 174091bp
    Select Tool
    Polypeptide UniProtKB:Q6PH71 (1) 395aa
    Sequence Clusters UniGene:18349 (1)
    Sequence Information (all 16)
    ORTHOLOGY for asah1b (Chr: 1)
    CITATIONS (26)