ZFIN ID: ZDB-GENE-030131-1421
Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene Symbol: serpina1
Previous Names: wu:fb61c07, wu:fb71a09, zgc:153807, zgc:158145
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: text only from Andreeva et al., 2015
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
  blood
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa18519 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH serpina1 HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    alpha 1-antitrypsin deficiency Emphysema due to AAT deficiency 613490
    Emphysema-cirrhosis, due to AAT deficiency 613490
    Hemorrhagic diathesis due to 'antithrombin' Pittsburgh 613490
    {Pulmonary disease, chronic obstructive, susceptibility to} 606963
    GENE ONTOLOGY 
    Ontology GO Term
    Cellular Component extracellular space (more)
    Molecular Function serine-type endopeptidase inhibitor activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000215 (1)
  • InterPro:IPR023795 (1)
  • InterPro:IPR023796 (1)
  • PROSITE:PS00284 (1)
  • Pfam:PF00079 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serpina1-001 (1) 1650
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM serpina1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    serpina1Contained in: [BAC] CH211-121D13 (order this)
    serpina1Encodes: [EST] fb61c07, fb71a09, IMAGE:6997096
    [cDNA] MGC:153807 (1) (order this), MGC:158145 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077758 (1) 1448bp
    Genomic GenBank:AL845550 (1) 163676bp
    Select Tool
    Polypeptide UniProtKB:Q6P5I9 (1) 435aa
    Sequence Clusters UniGene:75688 (1)
    Sequence Information (all 29)
    OTHER serpina1 GENE PAGES 
  • Gene:322701 (1)
  • VEGA:OTTDARG00000004306 (1)
  • Ensembl(GRCz10):ENSDARG00000090286 (1)
  • ORTHOLOGY for serpina1 (Chr: 20) 
    Species Symbol Chromosome Accession # Evidence
    Human SERPINA1 14
  • Gene:5265
  • OMIM:107400
  • HGNC:8941
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (15)