ZFIN ID: ZDB-GENE-030131-1421
Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene Symbol: serpina1
Previous Names: wu:fb61c07, wu:fb71a09, zgc:153807, zgc:158145
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: text only from Andreeva et al., 2015
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
  blood
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18519 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36986 Point Mutation Unknown Unknown ENU
    sa43393 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH serpina1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    alpha 1-antitrypsin deficiency Emphysema due to AAT deficiency 613490
    Emphysema-cirrhosis, due to AAT deficiency 613490
    Hemorrhagic diathesis due to 'antithrombin' Pittsburgh 613490
    {Pulmonary disease, chronic obstructive, susceptibility to} 606963
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component extracellular space (more)
    Molecular Function serine-type endopeptidase inhibitor activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000215 (1)
  • InterPro:IPR023795 (1)
  • InterPro:IPR023796 (1)
  • PROSITE:PS00284 (1)
  • Pfam:PF00079 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serpina1-001 (1) 1650
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM serpina1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    serpina1Contained in: [BAC] CH211-121D13 (order this)
    serpina1Encodes: [EST] fb61c07, fb71a09, IMAGE:6997096
    [cDNA] MGC:153807 (1) (order this), MGC:158145 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077758 (1) 1448bp
    Genomic GenBank:AL845550 (1) 163676bp
    Select Tool
    Polypeptide UniProtKB:Q6P5I9 (1) 435aa
    Sequence Clusters UniGene:75688 (1)
    Sequence Information (all 29)
    OTHER serpina1 GENE PAGES
  • Gene:322701 (1)
  • VEGA:OTTDARG00000004306 (1)
  • Ensembl(GRCz10):ENSDARG00000090286 (1)
  • ORTHOLOGY for serpina1 (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human SERPINA1 14
  • Gene:5265
  • OMIM:107400
  • HGNC:8941
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (15)