ZFIN ID: ZDB-GENE-030131-1421
Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene Symbol: serpina1
Previous Names: wu:fb61c07, wu:fb71a09, zgc:153807, zgc:158145
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION No data available
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa18519
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Emphysema due to AAT deficiency 613490
Emphysema-cirrhosis, due to AAT deficiency 613490
Hemorrhagic diathesis due to 'antithrombin' Pittsburgh 613490
{Pulmonary disease, chronic obstructive, susceptibility to} 606963
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of endopeptidase activity (more)
Cellular Component extracellular space (more)
Molecular Function serine-type endopeptidase inhibitor activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000215 (1)
  • InterPro:IPR023795 (1)
  • InterPro:IPR023796 (1)
  • PROSITE:PS00284 (1)
  • Pfam:PF00079 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serpina1-001 (1) 1650
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM serpina1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    serpina1 Contained in: [BAC] CH211-121D13 (order this)
    serpina1 Encodes: [EST] fb61c07, fb71a09, IMAGE:6997096
    [cDNA] MGC:153807 (1) (order this), MGC:158145 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077758 (1) 1448 bp
    Genomic GenBank:AL845550 (1) 163676 bp
    Select Tool
    Polypeptide UniProtKB:Q6P5I9 (1) 435 aa
    Sequence Clusters UniGene:75688 (1)
    Sequence Information (all 29)
    OTHER serpina1 GENE PAGES
  • Gene:322701 (1)
  • VEGA:OTTDARG00000004306 (1)
  • Ensembl(Zv9):ENSDARG00000090286 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish serpina1 20  
    Human SERPINA1 14 (14q32.1)
  • OMIM:107400
  • Gene:5265
  • Orthology Details
    CITATIONS (12)