Gene

tnfa

ID
ZDB-GENE-050317-1
Name
tumor necrosis factor a (TNF superfamily, member 2)
Symbol
tnfa Nomenclature History
Previous Names
  • TNF1 (1)
  • TNF-alpha 1 (1)
  • tnf-alpha
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have tumor necrosis factor receptor binding activity. Involved in several processes, including fin regeneration; intestinal epithelial structure maintenance; and response to bacterium. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; heart; male organism; pleuroperitoneal region; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).
Genome Resources
Note
None
Expression
All Expression Data
150 figures from 116 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, susceptibility to} 600807
migraine Alliance {Migraine without aura, susceptibility to} 157300
{Dementia, vascular, susceptibility to}
{Malaria, cerebral, susceptibility to} 611162
{Septic shock, susceptibility to}
Associated With tnfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006052 Tumour necrosis factor domain
Family IPR002959 Tumour necrosis factor alpha
Family IPR002960 Lymphotoxin-alpha
Family IPR006053 Tumour necrosis factor
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
Domain Details Per Protein
Protein Length Lymphotoxin-alpha Tumour necrosis factor Tumour necrosis factor alpha Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:Q1L8A5 234
UniProtKB:Q08CQ3 234
UniProtKB:Q6T9C7 234
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tnfa polyclonal IgG Rabbit
  • IHC
AnaSpec
12
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations