ZFIN ID: ZDB-GENE-050317-1
Gene Name: tumor necrosis factor a (TNF superfamily, member 2)
Gene Symbol: tnfa
Sequence Ontology ID : SO:0000704

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Previous Names: TNF1 (1), TNF-alpha 1 (1), tnf-alpha

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(Including Attributions)
Location: Chr: 19 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have cytokine activity and tumor necrosis factor receptor binding activity; involved in several processes, including autophagy, fin regeneration, and response to bacterium; predicted to  ...
GENE EXPRESSION
All Expression Data: 111 figures from 88 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16250 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43296 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH tnfa HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    migraine {Migraine without aura, susceptibility to} 157300
    {Dementia, vascular, susceptibility to}
    {Septic shock, susceptibility to}
    {Asthma, susceptibility to} 600807
    {Malaria, cerebral, susceptibility to} 611162
    DISEASE ASSOCIATED WITH tnfa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to bacterium (more)
    Cellular Component extracellular space (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002959 (1)
  • InterPro:IPR002960 (1)
  • InterPro:IPR006052 (1)
  • InterPro:IPR006053 (1)
  • InterPro:IPR008983 (1)
  • PROSITE:PS50049 (1)
  • Pfam:PF00229 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tnfa-201 (1) 1048
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tnfa
    MARKER RELATIONSHIPS
    tnfaContained in: [BAC] CH73-361O3 (1) (order this), CH211-127D20 (1) (order this), CH211-176D22 (1) (order this)
    tnfaEncodes: [cDNA] MGC:152825 (1) (order this), MGC:192241 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212859 (1) 1145bp
    Genomic GenBank:BX469886 151598bp
    Select Tool
    Polypeptide UniProtKB:Q08CQ3 (1) 234aa
    Sequence Clusters UniGene:89727 (1)
    Sequence Information (all 19)
    OTHER tnfa GENE PAGES
  • Alliance (1)
  • Gene:405785 (1)
  • VEGA:OTTDARG00000032572 (1)
  • Ensembl(GRCz11):ENSDARG00000009511 (2)
  • ORTHOLOGY for tnfa (Chr: 19)
    CITATIONS (370)