ZFIN ID: ZDB-GENE-030131-9102
Gene Name: collagen, type I, alpha 1a
Gene Symbol: col1a1a    Nomenclature History

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Previous Names: alpha1(I) (1), cb21 (1), col1a1, chi, chihuahua, med, microwaved, sb:cb21 (1), sb:cb384, wu:fa99c12, wu:fb02c06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Involved in several processes, including fin development; fin regeneration; and regulation of ossification. Localizes to cytoplasm. Used to study osteogenesis imperfecta and osteogenesis imperfecta type 3. Human ortholog(s) of this gene implicated in several diseases, including beta thalassemia; bone disease (multiple); cutaneous leishmaniasis; dermatofibrosarcoma protuberans; and tooth disease (multiple). Is expressed in several structures, including head; integument; myotome; osteoblast; and pectoral fin. Orthologous to human COL1A1 (collagen type I alpha 1 chain).
Genome Resources: Alliance (1),  Gene:337158 (1),  Ensembl(GRCz11):ENSDARG00000012405 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dc124 Point Mutation Unknown Missense ENU
dmh13 Point Mutation Unknown Nonsynonymous ENU
dmh14 Point Mutation Unknown Nonsynonymous ENU
sa1748 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25246 Point Mutation Unknown Splice Site ENU
    tt281 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-col1a1a N/A 1
    MO2-col1a1a N/A 1
    DISEASE ASSOCIATED WITH col1a1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Caffey disease Alliance Caffey disease 114000
    osteogenesis imperfecta type 1 Alliance Osteogenesis imperfecta, type I 166200
    osteogenesis imperfecta type 2 Alliance Osteogenesis imperfecta, type II 166210
    osteogenesis imperfecta type 3 Alliance Osteogenesis imperfecta, type III 259420
    osteogenesis imperfecta type 4 Alliance Osteogenesis imperfecta, type IV 166220
    osteoporosis Alliance {Bone mineral density variation QTL, osteoporosis} 166710
    Ehlers-Danlos syndrome, arthrochalasia type, 1 130060
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bone mineralization involved in bone maturation (more)
    Cellular Component cytoplasm (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col1a1a-201 (1)    Ensembl 5797
    ncRNA col1a1a-002 (1) 697
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col1a1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(col1a1a:EGFP) col1a1a EGFP Danio rerio 1 15
    MARKER RELATIONSHIPS
    col1a1a Contained in: [BAC] DKEY-31N5 (1) (order this)
    col1a1a Encodes: [EST] cb21 (2) (order this), cb384 (order this), fa99c12, fb02c06 (1)
    [cDNA] MGC:64229 (1), MGC:175062 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199214 (1) 5548 nt
    Genomic GenBank:AL929222 (1) 212599 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QJC9 (1) 1447 aa
    Sequence Information (all 34)
    ORTHOLOGY for col1a1a ( Chr: 3 )
    CITATIONS (122)