ZFIN ID: ZDB-GENE-040702-2
Gene Name: interleukin 1, beta
Gene Symbol: il1b    Nomenclature History

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Previous Name: zgc:111873

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cytokine activity; interleukin-1 receptor antagonist activity; and interleukin-1 receptor binding activity. Involved in several processes, including fin regeneration; leukocyte chemotaxis; and response to bacterium. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and lung disease (multiple). Is expressed in several structures, including brain; liver; male organism; pleuroperitoneal region; and trunk. Orthologous to human IL1B (interleukin 1 beta).
Genome Resources: Alliance (1),  Gene:405770 (1),  Ensembl(GRCz11):ENSDARG00000098700 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16617 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21819 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31807 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sh446 Small Deletion Exon 4 Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-il1b
    1
    CRISPR2-il1b
    1
    CRISPR3-il1b 1
    CRISPR4-il1b
    1
    MO1-il1b N/A 13
    MO2-il1b N/A 1
    MO3-il1b N/A 2
    PHENOTYPE
    Data: Fig. S2 from Ogryzko et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH il1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    stomach cancer Alliance {Gastric cancer risk after H. pylori infection} 137215
    DISEASE ASSOCIATED WITH il1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to bacterium (more)
    Cellular Component extracellular region (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB3-il1b monoclonal Mouse IHC 1
    Ab1-il1b polyclonal Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM il1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cryaa:DsRed,il1b:EGFP-F) cryaail1b DsRedEGFP Danio rerio 1 3
    Tg(hsp70l:il1b-EGFP) hsp70l EGFPil1b Danio rerio 1 3
    Tg(hsp70l:mCherry-2A-il1b) hsp70l 2Ail1bmCherry Danio rerio 1 1
    Tg(il1b:EGFP-F) il1b EGFP Danio rerio 1 7
    Tg(il1b:GFP-FTASE) il1b FTASEGFP Danio rerio 1 3
    tg(ins:il1b,cryaa:mcherry) cryaains il1bmCherry Danio rerio 0 1
    tg(ins:il1b-flag,cryaa:mcherry) cryaains FLAGil1bmCherry Danio rerio 1 1
    tgbac(il1b:egfp) il1b EGFP Danio rerio 1 3
    TgBAC(il1b:NTR-EGFP,cryaa:EGFP) cryaail1b EGFPNTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    il1b Encodes: [EST] eu384 (1)
    [cDNA] MGC:111873 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212844 (1)
    Genomic GenBank:CU695198 (1) 38893 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IYF1 (1) 284 aa
    Sequence Information (all 23)
    ORTHOLOGY for il1b ( Chr: 10 )
    CITATIONS (521)