ZFIN ID: ZDB-FIG-110929-20
Greenhill et al., 2011 - An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. PLoS Genetics   7(9):e1002265 Full text @ PLoS Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage Range: Prim-5 to Prim-25

Fig. 3

Residual melanocyte marker expression in sox10, mitfa, and sox10;mitfa mutants.

A–AB) Expression of dct, tyr, silva and tyrp1b in wild-type (WT), sox10t3, mitfaw2 and sox10t3; mitfaw2 mutants is shown at 24 and 36 hpf as indicated. Insets in each panel show enlargement of area of dorsal posterior trunk. Note the pronounced derepression of silva and dct, mild derepression of tyr, and minimal residual expression of tyrp1. Note that all in situs were over-developed in order to detect low level expression.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
dct WT standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2; sox10t3/t3 standard conditions Prim-25 trunk ISH
sox10t3/t3 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
pmela WT standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2; sox10t3/t3 standard conditions Prim-25 trunk ISH
sox10t3/t3 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
tyr WT standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2; sox10t3/t3 standard conditions Prim-25 trunk ISH
sox10t3/t3 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
tyrp1b WT standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2 standard conditions Prim-5 trunk ISH
Prim-25 trunk ISH
mitfaw2/w2; sox10t3/t3 standard conditions Prim-25 trunk ISH
sox10t3/t3 standard conditions Prim-5 Not Detected trunk ISH
Prim-25 Not Detected trunk ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal PLoS Genetics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS Genet.