ZFIN ID: ZDB-GENE-040718-249
Gene Name: tyrosinase-related protein 1b
Gene Symbol: tyrp1b
Previous Names: tyrp1 (1), hm:zeh0659, oca3, zgc:100893
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 12 figures from 9 publications
Directly Submitted Expression Data: 4 figures (14 images) from Thisse et al., 2004 [IMAGE:6894514]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
  eye, fin, hatching gland, integument (all 12) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-tyrp1b (1), MO2-tyrp1b (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Albinism, oculocutaneous, type III 203290
[Skin/hair/eye pigmentation, variation in, 11 (Melanesian blond hair)] 612271
GENE ONTOLOGY
Ontology GO Term
Biological Process melanosome organization (more)
Cellular Component melanosome membrane (more)
Molecular Function copper ion binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002227 (1)
  • InterPro:IPR008922 (1)
  • InterPro:IPR015559 (1)
  • PROSITE:PS00497 (1)
  • PROSITE:PS00498 (1)
  • Pfam:PF00264 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tyrp1b-001 (1) 1969
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tyrp1b
    Tg(tyrp1b:PALM-mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tyrp1b Contained in: [BAC] CH211-241E15 (1) (order this)
    tyrp1b Contains: [SNP] rs3727528 (1), rs3727529 (1)
    tyrp1b Encodes: [EST] fm95g09 (1), IMAGE:6894514 (1) (order this), zeh0659
    [cDNA] MGC:100893 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:BC076406 (1) 2000 bp
    Genomic GenBank:BX901913 (1) 142370 bp
    Select Tool
    Polypeptide UniProtKB:Q6DGE4 (1) 526 aa
    Sequence Information (all 7)
    OTHER tyrp1b GENE PAGES
  • VEGA:OTTDARG00000019511 (1)
  • Ensembl(Zv9):ENSDARG00000056151 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish tyrp1b 1  
    Human TYRP1 9 (9p23)
  • OMIM:115501
  • Gene:7306
  • Mouse Tyrp1 4 ( 37.89 cM)
  • MGI:98881
  • Gene:22178
  • Orthology Details
    CITATIONS (31)