Gene

tyrp1b

ID
ZDB-GENE-040718-249
Name
tyrosinase-related protein 1b
Symbol
tyrp1b Nomenclature History
Previous Names
  • tyrp1 (1)
  • hm:zeh0659
  • oca3
  • zgc:100893
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and oxidoreductase activity. Involved in several processes, including melanocyte differentiation; melanosome organization; and retinal pigment epithelium development. Predicted to localize to melanosome. Is expressed in several structures, including eye; hatching gland; immature eye; melanoblast; and pigment cell. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1).
Genome Resources
Note
None
Expression
All Expression Data
20 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tyrp1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
oculocutaneous albinism type III Alliance Albinism, oculocutaneous, type III 203290
[Skin/hair/eye pigmentation, variation in, 11 (Melanesian blond hair)] 612271
Associated With tyrp1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002227 Tyrosinase copper-binding domain
Homologous_superfamily IPR008922 Uncharacterised domain, di-copper centre
Domain Details Per Protein
Protein Length Tyrosinase copper-binding domain Uncharacterised domain, di-copper centre
UniProtKB:Q6DGE4 526
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations