ZFIN ID: ZDB-GENE-000508-1
Gene Name: dopachrome tautomerase
Gene Symbol: dct    Nomenclature History

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Previous Names: TRP-2, trp2, tyrosinase-related protein-2, zgc:109860

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have dopachrome isomerase activity. Predicted to be involved in developmental pigmentation; generation of neurons; and melanin biosynthetic process from tyrosine. Predicted to localize to melanosome. Is expressed in several structures, including eye; female organism; immature eye; integument; and neural crest. Orthologous to human DCT (dopachrome tautomerase).
Genome Resources: Alliance (1),  Gene:58074 (1),  Ensembl(GRCz11):ENSDARG00000006008 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016638Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21611 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34785 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dct HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dct VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dct-202 (1)    Ensembl 1472
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dct No data available
    MARKER RELATIONSHIPS
    dct Contained in: [Fosmid] CH1073-495O7 (1)
    dct Encodes: [cDNA] MGC:109860 (1), MGC:158512 (1), MGC:191397 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131555 (1) 1743 nt
    Genomic GenBank:CU694472 (1) 32900 nt
    Select Tool
    Polypeptide UniProtKB:A1L1Y0 (1) 513 aa
    Sequence Information (all 23)
    ORTHOLOGY for dct ( Chr: 9 )
    CITATIONS (133)