ZFIN ID: ZDB-FISH-150901-17912
Fish name: sox10t3/t3
Genotype: sox10t3/t3
Targeting Reagent: none
HUMAN DISEASE MODELED by sox10t3/t3
Human Disease Conditions Citations
Hirschsprung's disease control Rolig et al., 2017
Waardenburg's syndrome standard conditions Dutton et al., 2001
GENE EXPRESSION
Gene expression in sox10t3/t3
RNA expression
Expressed Gene Structure Conditions Figures
alcama standard conditions Fig. 3 with image from Carney et al., 2006
aldh1a3 standard conditions Fig. 4 from Dutton et al., 2009
bmp4 standard conditions Fig. 4 from Dutton et al., 2009
cx27.5 standard conditions Fig. 4 from Dutton et al., 2009
cx30.3 standard conditions Fig. 4 from Dutton et al., 2009
dct standard conditions Fig. 3 with image from Greenhill et al., 2011
fgf8a standard conditions Fig. 4Fig. 6 from Dutton et al., 2009
foxd3 standard conditions Fig. 6 with image from Lopes et al., 2008
Fig. 6 with image from Kelsh et al., 2000
fsta standard conditions Fig. 4 from Dutton et al., 2009
gfap standard conditions Fig. 7 with image from Kelsh et al., 2000
ltk standard conditions Fig. 5 with imageFig. 6 with image from Lopes et al., 2008
neurod1 standard conditions Fig. 8 from Dutton et al., 2009
neurog1 standard conditions Fig. 8 from Dutton et al., 2009
Fig. 5 with image from Carney et al., 2006
nfasca standard conditions Fig. 1 from Voas et al., 2009
nkx2.3 standard conditions Fig. S2 with image from Culbertson et al., 2011
pax2a standard conditions Fig. 4 from Dutton et al., 2009
pax5 standard conditions Fig. 4 from Dutton et al., 2009
phox2bb standard conditions Fig. 2 with image from Culbertson et al., 2011
pmela standard conditions Fig. 3 with image from Greenhill et al., 2011
snai1b standard conditions Fig. 8 from Dutton et al., 2009
Fig. 6 with image from Lopes et al., 2008
sox10 standard conditions Fig. 5 from Dutton et al., 2009
tyr standard conditions Fig. 3 with image from Greenhill et al., 2011
tyrp1b standard conditions Fig. 3 with image from Greenhill et al., 2011
wnt4 standard conditions Fig. 4 from Dutton et al., 2009
Protein expression
Antibody Antigen Genes Structure Conditions Figures
Ab1-col2a standard conditions Fig. 2 with image from Culbertson et al., 2011
Ab1-isl standard conditions Fig. 8 from Dutton et al., 2009
Ab1-elavl standard conditions Fig. 2 with image from Culbertson et al., 2011
Fig. 8 from Dutton et al., 2009
Fig. 3 with imageFig. 4 with imageFig. 6 with imageFig. 7 with image from Kelsh et al., 2000
zn-12 standard conditions Fig. 5 with image from Kelsh et al., 2000
Ab1-tuba standard conditions Fig. 1 from Voas et al., 2009
Fig. 5 with image from Kelsh et al., 2000
Ab1-scn standard conditions Fig. 1 from Voas et al., 2009
Ab1-pax2 standard conditions Fig. 2 with image from Culbertson et al., 2011
Reporter gene expression No data available
PHENOTYPE
Phenotype in sox10t3/t3
Phenotype Conditions Figures
anterior crista hair cell increased amount, abnormal standard conditions Fig. 7 from Dutton et al., 2009
anterior macula fused with posterior macula, abnormal standard conditions Fig. 7 from Dutton et al., 2009
anterior macula mislocalised, abnormal standard conditions Fig. 7 from Dutton et al., 2009
anterior semicircular canal aplastic, abnormal standard conditions Fig. 3 from Dutton et al., 2009
ceratobranchial cartilage morphology, normal standard conditions Fig. 2 with image from Culbertson et al., 2011
dorsal root ganglion decreased amount, abnormal standard conditions Fig. 3 with image from Carney et al., 2006
Fig. 4 with image from Kelsh et al., 2000
dorsal root ganglion mislocalised, abnormal standard conditions Fig. 3 with image from Carney et al., 2006
Fig. 4 with image from Kelsh et al., 2000
enteric nervous system glial cell decreased amount, abnormal standard conditions Fig. 7 with image from Kelsh et al., 2000
enteric nervous system neuron decreased amount, abnormal standard conditions Fig. 3 with image from Kelsh et al., 2000
enteric neuron absent, abnormal control Fig. S1 with image from Rolig et al., 2017
gut cell population proliferation increased occurrence, abnormal standard conditions Fig. 1 with image from Rolig et al., 2017
gut neutrophil increased amount, abnormal standard conditions Fig. 1 with image from Rolig et al., 2017
inner ear decreased size, abnormal standard conditions Table 3 from Whitfield et al., 1996
inner ear malformed, abnormal standard conditions Fig. 7 from Dutton et al., 2009
inner ear quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
intestinal motility process quality, abnormal control Fig. S1 with image from Rolig et al., 2017
iridophore decreased amount, abnormal standard conditions Fig. 1 with image from Elworthy et al., 2003
lateral line quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
macula hair cell mislocalised, abnormal standard conditions Fig. 7 from Dutton et al., 2009
melanoblast decreased amount, abnormal standard conditions Fig. 1 with image from Kelsh et al., 2000
Fig. 7 with image from Kelsh et al., 2000
melanocyte decreased amount, abnormal standard conditions Fig. 1 with image from Elworthy et al., 2003
Fig. 7 with image from Kelsh et al., 2000
melanocyte quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
melanocyte migration disrupted, abnormal standard conditions Fig. 7 with image from Kelsh et al., 2000
neural crest cell apoptotic, abnormal standard conditions Fig. 4 with image from Dutton et al., 2001
neural crest cell decreased amount, abnormal standard conditions Fig. 2 with image from Kelsh et al., 2000
neuromast quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
otic vesicle decreased size, abnormal standard conditions Fig. 3 from Dutton et al., 2009
otic vesicle distended, abnormal standard conditions Fig. 3 from Dutton et al., 2009
otic vesicle shape, abnormal standard conditions Fig. 3 from Dutton et al., 2009
otic vesicle epithelial cell apoptotic, abnormal standard conditions Fig. 8 from Dutton et al., 2009
otic vesicle hair cell increased amount, abnormal standard conditions Fig. 7 from Dutton et al., 2009
otolith decreased size, abnormal standard conditions Fig. 3 from Dutton et al., 2009
Table 3 from Whitfield et al., 1996
otolith quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
pigment cell quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
post-vent region melanoblast decreased amount, abnormal standard conditions Fig. 8 with image from Kelsh et al., 2000
posterior crista hair cell increased amount, abnormal standard conditions Fig. 7 from Dutton et al., 2009
posterior lateral line nerve defasciculated, abnormal standard conditions Fig. 3 from Voas et al., 2009
posterior lateral line nerve mislocalised, abnormal standard conditions Fig. 3 from Voas et al., 2009
posterior lateral line nerve axon decreased amount, abnormal standard conditions Fig. 3 from Voas et al., 2009
posterior lateral line nerve myelin sheath absent, abnormal standard conditions Fig. 3 from Voas et al., 2009
posterior lateral line nerve sodium channel complex asymmetrical, abnormal standard conditions Fig. 1 from Voas et al., 2009
posterior lateral line nerve sodium channel complex decreased amount, abnormal standard conditions Fig. 1 from Voas et al., 2009
posterior lateral line nerve sodium channel complex elongated, abnormal standard conditions Fig. 1 from Voas et al., 2009
posterior lateral line nerve sodium channel complex undistributed, abnormal standard conditions Fig. 1 from Voas et al., 2009
posterior macula mislocalised, abnormal standard conditions Fig. 7 from Dutton et al., 2009
posterior semicircular canal aplastic, abnormal standard conditions Fig. 3 from Dutton et al., 2009
semicircular canal decreased thickness, abnormal standard conditions Fig. 3 from Dutton et al., 2009
semicircular canal morphogenesis disrupted, abnormal standard conditions Fig. 3 from Dutton et al., 2009
sensory system quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
spinal cord dorsal side apoptotic, abnormal standard conditions Fig. 4 with image from Dutton et al., 2001
statoacoustic (VIII) ganglion neuron apoptotic, abnormal standard conditions Fig. 8 from Dutton et al., 2009
vagal ganglion malformed, abnormal standard conditions Fig. 2 with image from Culbertson et al., 2011
vagal ganglion morphology, normal standard conditions Fig. 2 with image from Culbertson et al., 2011
whole organism lacks all parts of type xanthophore, abnormal standard conditions Fig. 5 with image from Nagao et al., 2018
whole organism lacks all parts of type melanoblast, abnormal standard conditions Fig. 7 with image from Kelsh et al., 2000
whole organism lacks all parts of type iridophore, abnormal standard conditions Fig. 5 with image from Nagao et al., 2018
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)
whole organism viability, abnormal standard conditions Table 3 from Whitfield et al., 1996
xanthophore dead, abnormal standard conditions Fig. 4 with image from Dutton et al., 2001
xanthophore morphology, abnormal standard conditions Table 3 from Whitfield et al., 1996
xanthophore quality, abnormal standard conditions Fig. for (t3) from Phenotype Annotation (1994-2006)

CITATIONS  (23)