ZFIN ID: ZDB-GENE-030131-9818
Gene Name: premelanosome protein a
Gene Symbol: pmela    Nomenclature History

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Previous Names: pmel17 (1), cb397 (1), fading vision, fdv, sb:cb397, silva, wu:fc11g11, wu:fj24g11, zgc:136622

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and metal ion binding activity. Involved in eye pigmentation; melanocyte differentiation; and melanosome organization. Predicted to localize to the integral component of plasma membrane. Is expressed in several structures, including eye; immature eye; neural crest; notochord; and pigment cell. Orthologous to human PMEL (premelanosome protein).
Genome Resources: Alliance (1),  Gene:321239 (1),  Ensembl(GRCz11):ENSDARG00000091298 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mk209 Unknown Unknown Unknown CRISPR
th236a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ua5022 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pmela 1
    CRISPR2-pmela 1
    MO1-pmela N/A 2
    MO2-pmela N/A 2
    MO3-pmela N/A 1
    DISEASE ASSOCIATED WITH pmela HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pmela VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process amyloid fibril formation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000601 PKD domain
    Domain IPR011761 ATP-grasp fold
    Domain IPR022409 PKD/Chitinase domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR035986 PKD domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pmela-202 (1)    Ensembl 3163
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pmela No data available
    MARKER RELATIONSHIPS
    pmela Contained in: [BAC] CH73-290L19 (1)
    pmela Encodes: [EST] cb397 (1) (order this), fc11g11, fj24g11 (1)
    [cDNA] MGC:136622 (1), MGC:158124 (1), MGC:194959 (1), MGC:194963 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045330 (1) 2708 nt
    Genomic GenBank:CU695201 (1) 29701 nt
    Select Tool
    Polypeptide UniProtKB:B3DJD9 (1) 845 aa
    Sequence Information (all 40)
    ORTHOLOGY for pmela ( Chr: 11 )
    CITATIONS (44)