Gene

tyr

ID
ZDB-GENE-991026-3
Name
tyrosinase
Symbol
tyr Nomenclature History
Previous Names
  • oca1
  • sandy
  • sdy
  • tyra (1)
  • zgc:109705
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits catechol oxidase activity. Involved in several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to localize to integral component of membrane and melanosome membrane. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 20 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tyr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
oculocutaneous albinism type IA Alliance Albinism, oculocutaneous, type IA 203100
oculocutaneous albinism type IB Alliance Albinism, oculocutaneous, type IB 606952
Waardenburg syndrome/albinism, digenic 103470
[Skin/hair/eye pigmentation 3, blue/green eyes] 601800
[Skin/hair/eye pigmentation 3, light/dark/freckling skin] 601800
{Melanoma, cutaneous malignant, susceptibility to, 8} 601800
Associated With tyr Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002049 Laminin EGF domain
Domain IPR002227 Tyrosinase copper-binding domain
Homologous_superfamily IPR008922 Uncharacterised domain, di-copper centre
Domain Details Per Protein
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations