ZFIN ID: ZDB-GENE-991026-3
Gene Name: tyrosinase
Gene Symbol: tyr
Sequence Ontology ID : SO:0000704

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Previous Names: oca1, sandy, sdy, tyra (1), zgc:109705

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(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 16 figures from 16 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ck112a Insertion Exon 1 Premature Stop CRISPR
la019426Tg Transgenic Insertion Unknown Unknown DNA
la027655Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s901 Unknown Unknown Unknown ENU
    s3555 Point Mutation Unknown Unknown ENU
    te326 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk20 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm118 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to1 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to102 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty79 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tyr_unspecified Unspecified Unknown Unknown
    zf451 Indel Unknown Unknown CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 25 figures from 12 publications
    Observed in:
    DISEASE ASSOCIATED WITH tyr HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    ocular albinism with sensorineural deafness Waardenburg syndrome/albinism, digenic 103470
    oculocutaneous albinism Albinism, oculocutaneous, type IA 203100
    Albinism, oculocutaneous, type IB 606952
    oculocutaneous albinism type IA Albinism, oculocutaneous, type IA 203100
    oculocutaneous albinism type IB Albinism, oculocutaneous, type IB 606952
    [Skin/hair/eye pigmentation 3, blue/green eyes] 601800
    {Melanoma, cutaneous malignant, susceptibility to, 8} 601800
    [Skin/hair/eye pigmentation 3, light/dark/freckling skin] 601800
    DISEASE ASSOCIATED WITH tyr VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    oculocutaneous albinism tyrck112a/ck112a standard conditions Park et al., 2016
    color blindness tyrck112a/ck112a standard conditions Park et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catechol oxidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002049 (1)
  • InterPro:IPR002227 (1)
  • InterPro:IPR008922 (1)
  • PROSITE:PS00497 (1)
  • PROSITE:PS00498 (1)
  • Pfam:PF00053 (1)
  • Pfam:PF00264 (1)
  • EC:1.14.18.1 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM tyr No data available
    MARKER RELATIONSHIPS
    tyrEncodes: [EST] aj250302 (1)
    tyrHas Artifact: [cDNA] MGC:109705 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131013 (1)
    Genomic GenBank:CU856545 (1) 111121bp
    Select Tool
    Polypeptide UniProtKB:F1QDZ4 (1) 535aa
    Sequence Clusters UniGene:124526 (1)
    Sequence Information (all 34)
    OTHER tyr GENE PAGES
  • Alliance (1)
  • Gene:30207 (1)
  • Ensembl(GRCz11):ENSDARG00000039077 (1)
  • ORTHOLOGY for tyr (Chr: 15)
    CITATIONS (103)