ZFIN ID: ZDB-GENE-991026-3
Gene Name: tyrosinase
Gene Symbol: tyr    Nomenclature History

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Previous Names: oca1, sandy, sdy, tyra (1), zgc:109705

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits catechol oxidase activity. Involved in several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to colocalize with the melanosome. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism (multiple); oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Orthologous to human TYR (tyrosinase).
Genome Resources: Alliance (1),  Gene:30207 (1),  Ensembl(GRCz11):ENSDARG00000039077 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ck112a Insertion Exon 1 Premature Stop CRISPR
la019426Tg Transgenic Insertion Unknown Unknown DNA
la027655Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s901 Unknown Unknown Unknown ENU
    s3555 Point Mutation Unknown Unknown ENU
    te326 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk20 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm118 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to1 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to102 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty79 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tyr_unspecified Unspecified Unknown Unknown
    zf451 Indel Unknown Unknown CRISPR
    DISEASE ASSOCIATED WITH tyr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    oculocutaneous albinism type IA Alliance Albinism, oculocutaneous, type IA 203100
    oculocutaneous albinism type IB Alliance Albinism, oculocutaneous, type IB 606952
    Waardenburg syndrome/albinism, digenic 103470
    [Skin/hair/eye pigmentation 3, blue/green eyes] 601800
    [Skin/hair/eye pigmentation 3, light/dark/freckling skin] 601800
    {Melanoma, cutaneous malignant, susceptibility to, 8} 601800
    DISEASE ASSOCIATED WITH tyr VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    oculocutaneous albinism tyrck112a/ck112a standard conditions Park et al., 2016
    color blindness tyrck112a/ck112a standard conditions Park et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catechol oxidase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002049 Laminin EGF domain
    Domain IPR002227 Tyrosinase copper-binding domain
    Homologous_superfamily IPR008922 Uncharacterised domain, di-copper centre
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM tyr No data available
    MARKER RELATIONSHIPS
    tyr Encodes: [EST] aj250302 (1)
    tyr Has Artifact: [cDNA] MGC:109705 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131013 (1)
    Genomic GenBank:CU856545 (1) 111121 nt
    Select Tool
    Polypeptide UniProtKB:F1QDZ4 (1) 535 aa
    Sequence Information (all 33)
    ORTHOLOGY for tyr ( Chr: 15 )
    CITATIONS (123)