ZFIN

ZFIN ID: ZDB-GENE-040426-1971

ZFIN ID: ZDB-GENE-040426-1971

CITATIONS (72 total)

Gene Name:	growth arrest and DNA-damage-inducible, beta a
Gene Symbol:	gadd45ba

Liu, N., Zhang, S., Liu, Y., Lu, X., He, X. (2025) Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish. Journal of applied toxicology : JAT. :

Kong, S., Xiao, Y., Chen, L., Jin, Y., Qiao, R., Xu, K., Xu, L., Wang, H. (2024) Apigenin attenuates cisplatin-induced hair cell damage in the zebrafish lateral line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 194:115099

Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654

Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462

Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:

Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103

Valcarce, D.G., Riesco, M.F., Cuesta-Martín, L., Esteve-Codina, A., Martínez-Vázquez, J.M., Robles, V. (2023) Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. BMC Biology. 21:7070

Chatterjee, A., Maity, S., Banerjee, S., Dutta, S., Adhikari, M., Guchhait, R., Biswas, C., De, S., Pramanick, K. (2022) Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis. The Science of the total environment. 830:154796

Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043

Umamaheswari, S., Priyadarshinee, S., Kadirvelu, K., Ramesh, M. (2021) Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish. Chemico-biological interactions. 345:109550

Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264

Hu, J., Liu, J., Li, J., Lv, X., Yu, L., Wu, K., Yang, Y. (2020) Metal contamination, bioaccumulation, ROS generation, and epigenotoxicity influences on zebrafish exposed to river water polluted by mining activities. Journal of hazardous materials. 405:124150

Huang, W., Zheng, S., Wang, X., Cai, Z., Xiao, J., Liu, C., Wu, K. (2020) A transcriptomics-based analysis of toxicity mechanisms of zebrafish embryos and larvae following parental Bisphenol A exposure. Ecotoxicology and environmental safety. 205:111165

Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537

Liu, H., Duncan, K., Helverson, A., Kumari, P., Mumm, C., Xiao, Y., Carlson, J.C., Darbellay, F., Visel, A., Leslie, E., Breheny, P., Erives, A.J., Cornell, R.A. (2020) Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. eLIFE. 9:

Spreafico, M., Gruszka, A.M., Valli, D., Mazzola, M., Deflorian, G., Quintè, A., Totaro, M.G., Battaglia, C., Alcalay, M., Marozzi, A., Pistocchi, A. (2020) HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. 8:844

Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252

Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):

Boulanger, E., Barst, B.D., Alloy, M.M., Blais, S., Houde, M., Head, J.A. (2019) Assessment of environmentally contaminated sediment using a contact assay with early life stage zebrafish (Danio rerio). The Science of the total environment. 659:950-962

Zhai, X., Wang, L., Xu, C., Hou, Q., Zhang, L., Li, Z., Qin, W., Liu, Z., Chen, Z. (2019) Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. Archives of biochemistry and biophysics. 671:210-217

Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422

Simon, O., Barjhoux, I., Camilleri, V., Gagnaire, B., Cavalié, I., Orjollet, D., Darriau, F., Pereira, S., Beaugelin-Seillers, K., Adam-Guillermin, C. (2018) Uptake, depuration, dose estimation and effects in zebrafish exposed to Am-241 via dietary route. Journal of Environmental Radioactivity. 193-194:68-74

Wang, L., Zhang, L., Hou, Q., Zhu, X., Chen, Z., Liu, Z. (2018) Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B. Scientific Reports. 8:10843

Gombeau, K., Bourdineaud, J.P., Ravanat, J.L., Armant, O., Camilleri, V., Cavalie, I., Floriani, M., Adam-Guillermin, C. (2017) Epigenetic, histopathological and transcriptomic effects following exposure to depleted uranium in adult zebrafish and their progeny. Aquatic toxicology (Amsterdam, Netherlands). 184:14-25

Singh, R., Khatri, P., Srivastava, N., Jain, S., Bramchari, V., Mukhopadhyay, A., Mazumder, S. (2017) Fluoride exposure abates pro-inflammatory response and induces in vivo apoptosis rendering zebrafish (Danio rerio) susceptible to bacterial infections. Fish & shellfish immunology. 63:314-321

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Chen, Z., Wan, X., Hou, Q., Shi, S., Wang, L., Chen, P., Zhu, X., Zeng, C., Qin, W., Zhou, W., Liu, Z. (2016) GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway. Cell Death & Disease. 7:e2068

Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y.A., Hamrick, M.W. (2016) Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochemical and Biophysical Research Communications. 479(3):590-595

Dedeh, A., Ciutat, A., Treguer-Delapierre, M., Bourdineaud, J.P. (2015) Impact of gold nanoparticles on zebrafish exposed to a spiked sediment. Nanotoxicology. 9:71-80

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Huang, Y., Linsen, S.E. (2015) Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. BMC Genomics. 16:427

Noce, I.D., Carra, S., Brusegan, C., Critelli, R., Frassine, A., De Lorenzo, C., Giordano, A., Bellipanni, G., Villa, E., Cotelli, F., Pistocchi, A., Schepis, F. (2015) The Coiled-Coil Domain Containing 80 (ccdc80) Gene Regulates gadd45β2 Expression in the Developing Somites of Zebrafish as a New Player of the Hedgehog Pathway. Journal of Cellular Physiology. 230(4):821-30

Chen, Y.Y., Zhu, J.Y., Chan, K.M. (2014) Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells. Aquatic toxicology (Amsterdam, Netherlands). 157C:196-206

Fiaz, A. W., Léon-Kloosterziel, K. M., van Leeuwen, J. L., Kranenbarg, S. (2014) Exploring the effect of exercise on the transcriptome of zebrafish larvae (Danio rerio). Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):728-739

Garcia-Reyero, N., Escalon, B.L., Prats, E., Stanley, J.K., Thienpont, B., Melby, N.L., Barón, E., Eljarrat, E., Barceló, D., Mestres, J., Babin, P.J., Perkins, E.J., and Raldúa, D. (2014) Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environment International. 63:216-223

Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002

Shimoda, N., Hirose, K., Kaneto, R., Izawa, T., Yokoi, H., Hashimoto, N., Kikuchi, Y. (2014) No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos. PLoS One. 9:e114816

Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632

Hirose, K., Shimoda, N., and Kikuchi, Y. (2013) Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics. 8(9):899-906

Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764

Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109

Orieux, N., Cambier, S., Gonzalez, P., Morin, B., Adam, C., Garnier-Laplace, J., and Bourdineaud, J.P. (2011) Genotoxic damages in zebrafish submitted to a polymetallic gradient displayed by the Lot River (France). Ecotoxicology and environmental safety. 74(4):974-983

Zucchi, S., Oggier, D.M., and Fent, K. (2011) Global gene expression profile induced by the UV-filter 2-ethyl-hexyl-4-trimethoxycinnamate (EHMC) in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 159(10):3086-96

Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942

Lerebours, A., Gonzalez, P., Adam, C., Camilleri, V., Bourdineaud, J.P., and Garnier-Laplace, J. (2009) Comparative Analysis Of Gene Expression In Brain, Liver, Skeletal Muscles And Gills Of The Zebrafish (Danio rerio) Exposed To Environmentally Relevant Waterborne Uranium Concentrations. Environmental toxicology and chemistry. 28(6):1271-1278

Lim, C.H., Chong, S.W., and Jiang, Y.J. (2009) Udu deficiency activates DNA damage checkpoint. Molecular biology of the cell. 20(19):4183-4193

Krishnan, K., Salomonis, N., and Guo, S. (2008) Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 3(11):e3621

Rai, K., Huggins, I.J., James, S.R., Karpf, A.R., Jones, D.A., and Cairns, B.R. (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 135(7):1201-1212

Gonzalez, P., Baudrimont, M., Boudou, A., and Bourdineaud, J.P. (2006) Comparative Effects of Direct Cadmium Contamination on Gene Expression in Gills, Liver, Skeletal Muscles and Brain of the Zebrafish (Danio rerio). Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 19(3):225-235

Hoffmann, J.L., Torontali, S.P., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., Versteeg, D.J. (2006) Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Aquatic toxicology (Amsterdam, Netherlands). 79(3):233-246

Gonzalez, P., Dominique, Y., Massabuau, J.C., Boudou, A., and Bourdineaud, J.P. (2005) Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environmental science & technology. 39(11):3972-3980

Kawahara, A., Che, Y.S., Hanaoka, R., Takeda, H., and Dawid, I.B. (2005) Zebrafish GADD45{beta} genes are involved in somite segmentation. Proceedings of the National Academy of Sciences of the United States of America. 102(2):361-366

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Lewis, K.E., and Eisen, J.S. (2004) Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity. Development (Cambridge, England). 131(4):891-902

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Durbin, L., Sordino, P., Barrios, A., Gering, M., Thisse, C., Thisse, B., Brennan, C., Green, A., Wilson, S., and Holder, N. (2000) Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development (Cambridge, England). 127(8):1703-1713

Additional Citations (16):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

Thisse, B., Pflumio, S., Fürthauer, M., Loppin, B., Heyer, V., Degrave, A., Woehl, R., Lux, A., Steffan, T., Charbonnier, X.Q. and Thisse, C. (2001) Expression of the zebrafish genome during embryogenesis (NIH R01 RR15402). ZFIN Direct Data Submission.