PUBLICATION
Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings
- Authors
- Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X.
- ID
- ZDB-PUB-181224-20
- Date
- 2018
- Source
- Environmental pollution (Barking, Essex : 1987) 246: 414-422 (Journal)
- Registered Authors
- Keywords
- Organs, Silver nanoparticle, Toxicity, Zebrafish
- MeSH Terms
-
- Animals
- Citric Acid/chemistry
- Citric Acid/toxicity
- Povidone/chemistry
- Povidone/toxicity
- Silver/chemistry*
- Silver/toxicity
- Zebrafish/anatomy & histology
- Zebrafish/genetics
- Zebrafish/physiology*
- Gene Expression/drug effects
- Water Pollutants, Chemical/chemistry*
- Water Pollutants, Chemical/toxicity*
- Particle Size
- Metal Nanoparticles/chemistry*
- Metal Nanoparticles/toxicity
- PubMed
- 30579210 Full text @ Environ. Pollut.
Citation
Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422.
Abstract
Silver nanoparticles (AgNPs) in aquatic ecosystems are toxic to aquatic organisms. In this study, we aimed to investigate the toxicities and molecular mechanisms of AgNPs with different surface coatings (sodium citrate and polyvinylpyrrolidone) and particle sizes (20 nm and 100 nm) in the gills, intestines, and muscles of zebrafish after 96 h of exposure. Our results indicated that the contribution of particle size to AgNP toxicity was greater than that of the surface coating. Citrate-coated AgNPs were more toxic than polyvinylpyrrolidone-coated AgNPs, and 20-nm AgNPs were more toxic than 100-nm AgNPs. The toxic effects of AgNPs to the tissues were in the order intestines > gills > muscles. Differential expression of genes with the different AgNPs confirmed that they had toxic effects in the zebrafish tissues at the molecular level. Our comprehensive comparison of the toxicities of different AgNPs to aquatic ecosystems will be helpful for further risk assessments of AgNPs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping