FIGURE

Fig. 8.

ID

ZDB-FIG-260319-35

Publication

Lee et al., 2026 - Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a zebrafish model of MPSIVA

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Fig. 8.

RNA-sequencing analyses reveal changes in transcript expression levels of multiple genes associated with MAPK signaling and vascular and ocular development. (A) Volcano plot highlights numerous genes with increased or decreased transcript expression in galns^m/m mutant larvae. FDR, false discovery rate. (B) Gene Ontology (GO) analyses suggest that the most significant changes in transcript expression occur in genes associated with inhibition of MAPK activity, lens fiber differentiation and multiple aspects of blood vessel regulation. (C) Table shows genes for which transcript changes were associated with key GO categories implicated in mutant larvae. DE, differentially expressed. (D) Heat maps show the degree of change in specific genes for the identified GO categories. The P-value associated with their change is listed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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