Gene

pitx3

ID
ZDB-GENE-041229-4
Name
paired-like homeodomain 3
Symbol
pitx3 Nomenclature History
Previous Names
  • zgc:109716
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development; lens fiber cell differentiation; and positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; immature eye; nervous system; and neurogenic field. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
61 figures from 34 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pitx3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 1 Alliance Anterior segment dysgenesis 1, multiple subtypes 107250
cataract 11 multiple types Alliance Cataract 11, multiple types 610623
cataract 11 multiple types Alliance Cataract 11, syndromic, autosomal recessive 610623
Associated With pitx3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Domain IPR020479 Homeobox domain, metazoa
Family IPR016233 Homeobox protein Pitx/unc30
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily Homeobox protein Pitx/unc30 OAR domain
UniProtKB:Q6QU75 293
UniProtKB:A0A2R8PVD5 306
UniProtKB:A0A0R4ISS1 280
UniProtKB:B2GRZ8 293
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pitx3 polyclonal IgG Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations