Gene
dusp1
- ID
- ZDB-GENE-040426-2018
- Name
- dual specificity phosphatase 1
- Symbol
- dusp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of MAPK cascade; and protein dephosphorylation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including forebrain neural keel; margin; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb269 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR001763 | Rhodanese-like domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
Domain | IPR020422 | Dual specificity protein phosphatase domain |
Family | IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
Domain Details Per Protein
Protein | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6IQU5
|
360 | |||||||||
UniProtKB:Q7ZVL8
|
360 | |||||||||
UniProtKB:A0A0R4IS50
|
369 |
Interactions and Pathways
No data available
Plasmids
No data available