Gene
hsf4
- ID
- ZDB-GENE-050306-18
- Name
- heat shock transcription factor 4
- Symbol
- hsf4 Nomenclature History
- Previous Names
-
- zgc:113344
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in lens fiber cell differentiation and maintenance of lens transparency. Acts upstream of or within several processes, including lens morphogenesis in camera-type eye; positive regulation of deoxyribonuclease activity; and regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in eye; lens; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hzu5 | Allele with one deletion | Exon 1 | Unknown | TALEN |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hsf4 | Morishita et al., 2021 | |
| MO1-hsf4 | N/A | (2) |
| MO2-hsf4 | N/A | Swan et al., 2012 |
| TALEN1-hsf4 | (4) |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 5 multiple types | Alliance | Cataract 5, multiple types | 116800 |
1 - 1 of 1
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | WT + MO1-hsf4 | standard conditions | Cui et al., 2013 |
| cataract | hsf4hzu5/hzu5 | standard conditions | Cui et al., 2019 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000232 | Heat shock factor (HSF)-type, DNA-binding |
| Domain | IPR010542 | Vertebrate heat shock transcription factor, C-terminal domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
1 - 4 of 4
Domain Details Per Protein
| Protein | Additional Resources | Length | Heat shock factor (HSF)-type, DNA-binding | Vertebrate heat shock transcription factor, C-terminal domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q5CZP2 | InterPro | 441 | ||||
| UniProtKB:A0A8M3AJJ3 | InterPro | 424 | ||||
| UniProtKB:A0A8M9PQ64 | InterPro | 441 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-3L5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113344 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192359 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328208 (1) | 2102 nt | ||
| Genomic | GenBank:BX088710 (1) | 65734 nt | ||
| Polypeptide | UniProtKB:A0A8M9PQ64 (1) | 441 aa |
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Morishita, H., Eguchi, T., Tsukamoto, S., Sakamaki, Y., Takahashi, S., Saito, C., Koyama-Honda, I., Mizushima, N. (2021) Organelle degradation in the lens by PLAAT phospholipases. Nature. 592(7855):634-638
- Zhang, J., Cui, W.W., Du, C., Huang, Y., Pi, X., Guo, W., Wang, J., Huang, W., Chen, D., Li, J., Li, H., Zhang, J., Ma, Y., Mu, H., Zhang, S., Liu, M., Cui, X., Hu, Y. (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1866:165724
- Cui, X., Feng, R., Wang, J., Du, C., Pi, X., Chen, D., Li, J., Li, H., Zhang, J., Zhang, J., Mu, H., Zhang, F., Liu, M., Hu, Y. (2019) Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens. Biochimica et biophysica acta. General subjects. 1864(3):129496
- Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., Yang, W., Yu, L., Xiao, Z.X., Feng, X.H., Wang, H., Yuan, Z.M., Peng, J., Tan, W.Q., Chen, J. (2019) p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports. 29:3693-3707.e5
- Cukrov, D., Newman, T., Leask, M., Leeke, B., Sarogni, P., Patimo, A., Kline, A.D., Krantz, I.D., Horsfield, J., Musio, A. (2018) Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human molecular genetics. 27(17):3002-3011
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
- Gao, M., Huang, Y., Wang, L., Huang, M., Liu, F., Liao, S., Yu, S., Lu, Z., Han, S., Hu, X., Qu, Z., Liu, X., Assefa Yimer, T., Yang, L., Tang, Z., Li, D.W., Liu, M. (2017) HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death & Disease. 8:e3082
1 - 10 of 14
Show