Gene
ada
- ID
- ZDB-GENE-040718-393
- Name
- adenosine deaminase
- Symbol
- ada Nomenclature History
- Previous Names
-
- ada1 (1)
- zgc:92028
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables adenosine deaminase activity. Predicted to be involved in several processes, including hypoxanthine salvage; negative regulation of adenosine receptor signaling pathway; and purine ribonucleoside metabolic process. Predicted to be located in several cellular components, including anchoring junction; cytoplasmic vesicle lumen; and lysosome. Predicted to be active in cytosol and external side of plasma membrane. Is expressed in several structures, including digestive system; gill; heart; kidney; and muscle. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911877 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adenosine deaminase deficiency | Alliance | Adenosine deaminase deficiency, partial | 102700 |
| adenosine deaminase deficiency | Alliance | Severe combined immunodeficiency due to ADA deficiency | 102700 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenosine/adenine deaminase | Adenosine/AMP deaminase active site | Adenosine deaminase | Adenosine deaminase domain | Metal-dependent hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DG22 | InterPro | 359 |
Interactions and Pathways
No data available
Plasmids
No data available