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Gene

ctsba

ID
ZDB-GENE-040426-2650
Name
cathepsin Ba
Symbol
ctsba Nomenclature History
Previous Names
  • ctsb
  • id:ibd1201
  • wu:fa13g05
  • wu:fb34e12
  • zgc:55862
  • zgc:65809
  • zgc:77181 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within dorsal/ventral pattern formation; fin regeneration; and morphogenesis of an epithelium. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including blastoderm cell; endocrine system; macrophage; midbrain hindbrain boundary; and yolk. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Langdon et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctsba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Keratolytic winter erythema 148370
Associated With ctsba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR012599 Peptidase C1A, propeptide
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine peptidase superfamily Peptidase C1A, papain C-terminal Peptidase C1A, propeptide
UniProtKB:Q803E4 330
UniProtKB:E9QDX8 283
UniProtKB:Q6PH75 330
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations