Gene

dusp4

ID

ZDB-GENE-040426-709

Name

dual specificity phosphatase 4

Symbol

dusp4 Nomenclature History

Previous Names

zgc:55423

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of endodermal cell differentiation; and negative regulation of fibroblast growth factor receptor signaling pathway. Acts upstream of or within endodermal cell fate specification. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; margin; nervous system; polster; and tail bud. Orthologous to human DUSP4 (dual specificity phosphatase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55423 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dusp4 Human Ortholog

No data available

Associated With dusp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000340	Dual specificity phosphatase, catalytic domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR001763	Rhodanese-like domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR020422	Dual specificity protein phosphatase domain
Family	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036873	Rhodanese-like domain superfamily