FIGURE

Fig. 4

ID

ZDB-FIG-230801-5

Publication

Wilson et al., 2022 - Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos

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Fig. 4

Gene expression summary. (a) Expression of 547 and 419 genes was significantly changed (p < .05) by tris(4-chlorophenyl)methanol (TCPMOH) and tris(4-chlorophenyl)methane (TCPM) exposure, respectively, with 237 genes significantly changed by both. A total of 101 genes were differentially expressed between TCPMOH and TCPM exposure and 35 genes were significantly altered across all group comparisons. (b) The top five upregulated genes by treatment group. (c) The top five down regulated genes by treatment group

Expression Data

Genes:	btg2 cry5 cyp1a egr1 egr4 fosab lonrf1 npas4a nr4a1 per2 xpc (all 11)
Fish:	AB
Conditions:	chemical treatment by environment: tris(4-chlorophenyl)methane chemical treatment by environment: tris(4-chlorophenyl)methanol
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: tris(4-chlorophenyl)methane chemical treatment by environment: tris(4-chlorophenyl)methanol
Observed In:	cell cycle circadian rhythm DNA replication MAPK cascade nucleotide-excision repair retinol metabolic process RNA catabolic process steroid hormone biosynthetic process Toll signaling pathway tyrosine metabolic process whole organism (all 11)
Stage:	Day 4

Phenotype Detail

Acknowledgments

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