Gene

cyp1a

ID
ZDB-GENE-011219-1
Name
cytochrome P450, family 1, subfamily A
Symbol
cyp1a Nomenclature History
Previous Names
  • cyp1a1 (1)
  • zfCYP1A
  • wu:fb63b04 (1)
  • zgc:109747
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have monooxygenase activity. Involved in cellular aromatic compound metabolic process; cellular response to organic cyclic compound; and cellular response to xenobiotic stimulus. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CYP1A1 (cytochrome P450 family 1 subfamily A member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
114 figures from 53 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp1a Human Ortholog
No data available
Associated With cyp1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR008066 Cytochrome P450, E-class, group I, CYP1
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450, E-class, group I, CYP1 Cytochrome P450 superfamily
UniProtKB:O93324 75
UniProtKB:Q8UW07 519
UniProtKB:Q6TH23 519
UniProtKB:Q504K4 518
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cyp1a monoclonal IgG3 , k Mouse
  • IHC
Cayman Chemical Company
Biosense Laboratories
10
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations