Gene

cyp1a

ID

ZDB-GENE-011219-1

Name

cytochrome P450, family 1, subfamily A

Symbol

cyp1a Nomenclature History

Previous Names

cyp1a1 (1)
zfCYP1A
wu:fb63b04 (1)
zgc:109747

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable monooxygenase activity. Acts upstream of or within cellular response to organic cyclic compound and cellular response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1) and CYP1A2 (cytochrome P450 family 1 subfamily A member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

124 figures from 62 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7163229 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp1a Human Ortholog

No data available

Associated With cyp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Family	IPR008066	Cytochrome P450, E-class, group I, CYP1
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily