Gene
xpc
- ID
- ZDB-GENE-030131-8461
- Name
- xeroderma pigmentosum, complementation group C
- Symbol
- xpc Nomenclature History
- Previous Names
-
- wu:fb12d05
- wu:fb12d09
- zgc:113032
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in mismatch repair and nucleotide-excision repair. Predicted to localize to XPC complex; cytoplasm; and nucleotide-excision repair factor 2 complex. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Is expressed in liver. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113032 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xeroderma pigmentosum group C | Alliance | Xeroderma pigmentosum, group C | 278720 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR018325 | Rad4/PNGase transglutaminase-like fold |
| Domain | IPR018326 | Rad4 beta-hairpin domain 1 |
| Domain | IPR018327 | Rad4 beta-hairpin domain 2 |
| Domain | IPR018328 | Rad4 beta-hairpin domain 3 |
| Family | IPR004583 | DNA repair protein Rad4 |
| Family | IPR018026 | DNA repair protein Rad4-like |
| Homologous_superfamily | IPR036985 | Transglutaminase-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
| Homologous_superfamily | IPR042488 | Rad4, beta-hairpin domain 3 superfamily |
Domain Details Per Protein
| Protein | Length | DNA repair protein Rad4 | DNA repair protein Rad4-like | Papain-like cysteine peptidase superfamily | Rad4 beta-hairpin domain 1 | Rad4 beta-hairpin domain 2 | Rad4 beta-hairpin domain 3 | Rad4, beta-hairpin domain 3 superfamily | Rad4/PNGase transglutaminase-like fold | Transglutaminase-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQU6
|
844 | |||||||||
|
UniProtKB:Q1LVE4
|
879 |
Interactions and Pathways
No data available
Plasmids
No data available