Gene
per2
- ID
- ZDB-GENE-011220-2
- Name
- period circadian clock 2
- Symbol
- per2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Predicted to be active in cytoplasm and nucleus. Is expressed in heart; liver; muscle; nervous system; and ovary. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 1. Orthologous to human PER2 (period circadian regulator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| advanced sleep phase syndrome 1 | Alliance | ?Advanced sleep phase syndrome, familial, 1 | 604348 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PAS domain | PAS domain superfamily | PAS fold-3 | Period circadian-like, C-terminal | Period circadian protein homolog 1-3, PAS-A domain | Period circadian regulator |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QUT1
|
1399 | ||||||
|
UniProtKB:A0A8M9PS01
|
1417 | ||||||
|
UniProtKB:A0A8M9QFB2
|
1418 |
Interactions and Pathways
No data available
Plasmids