FIGURE

Fig. 3

ID

ZDB-FIG-230801-4

Publication

Wilson et al., 2022 - Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos

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Fig. 3

Pancreas length. Tg(ptf1a::GFP) Zebrafish embryos were imaged and measured at 96 hpf following exposure to 50 nM tris(4-chlorophenyl)methanol (TCPMOH), 50 nM tris(4-chlorophenyl)methane (TCPM), or 0.01% dimethyl sulfoxide (DMSO). Asterisks (*) designate statistically significant changes from controls (p < .05). n = 26–32 embryos per exposure group. (a) The mean pancreas length of embryos exposed to 50 nM TCPMOH was reduced by 6%, compared to controls. The mean pancreas length of embryos exposed to 50 nM TCPM was 2.7% larger than the controls. (b) The incidence of hypo- and hypermorphic pancreas lengths was increased to 25% (each) in embryos exposed to TCPMOH.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jh1Tg/jh1Tg
Conditions:	chemical treatment by environment: tris(4-chlorophenyl)methane chemical treatment by environment: tris(4-chlorophenyl)methanol
Observed In:	pancreas
Stage:	Day 4

Phenotype Detail

Acknowledgments

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