MAPK cascade

Term ID

GO:0000165

Synonyms

ERK/MAPK cascade
MAP kinase cascade
MAP kinase kinase kinase cascade
MAPK signal transduction
MAPK signaling
MAPK signalling
MAPKKK cascade
MAPKKK cascade during sporulation
mitogen-activated protein kinase cascade

Definition

An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. (2)

References

Reactome:R-HSA-169893
Reactome:R-HSA-5673001
Wikipedia:MAPK_cascade
Wikipedia:Mitogen-activated_protein_kinase

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP-kinase scaffold activity

MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP-kinase scaffold activity Show first 5 Terms
is a type of: intracellular signaling cassette

intracellular signaling cassette Show first 5 Terms
has subtype: ERK1 and ERK2 cascade ERK5 cascade JNK cascade p38MAPK cascade pheromone response MAPK cascade ... Show All 6 Terms

ERK1 and ERK2 cascade ERK5 cascade JNK cascade p38MAPK cascade pheromone response MAPK cascade stress-activated MAPK cascade Show first 5 Terms
negatively regulated by: negative regulation of MAPK cascade

negative regulation of MAPK cascade Show first 5 Terms
positively regulated by: positive regulation of MAPK cascade positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of MAPK cascade positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Show first 5 Terms
regulated by: regulation of MAPK cascade

regulation of MAPK cascade Show first 5 Terms

Phenotype

Phenotype caused by Genes