FIGURE

Figure 7

ID

ZDB-FIG-230330-26

Publication

Sobah et al., 2023 - Socs3b regulates the development and function of innate immune cells in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 7

Eye pathology in socs3b KO zebrafish. Representative images of wildtype (WT, socs3b^wt/wt) and symptomatic knockout (KO, socs3b^mdu24/mdu24) zebrafish on either the Tg(mpx::GFP) (A, B) or Tg(mpeg1.1::GFP) (C) background, with close-up of right eye from respective zebrafish (B, C) under light (left panels) and fluorescence (right panels) microscopy, with scale bar representing 1 cm. Incidence of eye pathology (D) and overall survival (E) in WT and KO zebrafish (n = 25), with significance determined using a log-rank test. Gene expression analysis of WT and symptomatic KO adult eye showing mean and SEM (n = 6) (F). Normalized Cq values obtained from WT and KO eyes was used to test for significance using parametric t-tests (*** p < 0.001, ** p < 0.01, * p < 0.05).

Expression Data

Genes:	cxcr3.2 il1b il4 il6 il21 tnfa
Fish:	socs3b^mdu24/mdu24
Anatomical Term:	eye
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	socs3b^mdu24/mdu24 socs3b^mdu24/mdu24; gl22Tg/gl22Tg socs3b^mdu24/mdu24; i114Tg/i114Tg
Observed In:	eye eye macrophage eye neutrophil whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol