Gene
il21
- ID
- ZDB-GENE-120510-4
- Name
- interleukin 21
- Symbol
- il21 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of natural killer cell mediated cytotoxicity. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region. Is expressed in several structures, including gill; heart; immune system; liver; and muscle. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 11 | Alliance | ?Immunodeficiency, common variable, 11 | 615767 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Interleukin-15/Interleukin-21 family |
|---|---|---|---|
|
UniProtKB:A1YYP5
|
151 | ||
|
UniProtKB:A0A8M2BKC7
|
144 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available