Gene
cxcr3.2
- ID
- ZDB-GENE-041114-186
- Name
- chemokine (C-X-C motif) receptor 3, tandem duplicate 2
- Symbol
- cxcr3.2 Nomenclature History
- Previous Names
-
- dr-chr16-CXCR3-37.5-EK27053
- zgc:92301
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within several processes, including leukocyte migration involved in immune response; macrophage activation involved in immune response; and macrophage chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in blood island; endothelial cell; and macrophage. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu272 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu6044 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa253 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5887 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa8709 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cxcr3.2 | Uusi-Mäkelä et al., 2018 | |
| MO1-cxcr3.2 | N/A | Zakrzewska et al., 2010 |
| MO2-cxcr3.2 | N/A | Zakrzewska et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Angiotensin II receptor family | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:E9QJ73
|
378 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcr3.2-201
(1)
|
Ensembl | 1,893 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81P7 | ||
| Contained in | BAC | DKEY-269D20 | ZFIN Curated Data | |
| Encodes | EST | eu272 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:92301 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007314 (1) | 1922 nt | ||
| Genomic | GenBank:BX005342 (1) | 257502 nt | ||
| Polypeptide | UniProtKB:E9QJ73 (1) | 378 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Sanchez-Gonzalez, R., Koupourtidou, C., Lepko, T., Zambusi, A., Novoselc, K.T., Durovic, T., Aschenbroich, S., Schwarz, V., Breunig, C.T., Straka, H., Huttner, H.B., Irmler, M., Beckers, J., Wurst, W., Zwergal, A., Schauer, T., Straub, T., Czopka, T., Trümbach, D., Götz, M., Stricker, S.H., Ninkovic, J. (2022) Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 11(3):
- Valdés, N., Cortés, M., Barraza, F., Reyes-López, F.E., Imarai, M. (2022) CXCL9-11 chemokines and CXCR3 receptor in teleost fish species. Fish and shellfish Immunology reports. 3:100068100068
- Gu, L., Peng, S., Zhang, J., Lu, X., Xia, C., Yu, J., Sun, L. (2021) Development and validation of an activated immune model with zebrafish eleutheroembryo based on caudal fin acupuncture. The Science of the total environment. 785:147288
- Kulkarni, A., Pineros, A.R., Walsh, M.A., Casimiro, I., Ibrahim, S., Hernandez-Perez, M., Orr, K.S., Glenn, L., Nadler, J.L., Morris, M.A., Tersey, S.A., Mirmira, R.G., Anderson, R.M. (2021) 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. JCI insight. 6(14):
- Sommer, F., Torraca, V., Xie, Y., In 't Veld, A.E., Willemse, J., Meijer, A.H. (2021) Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal. Cell Reports. 35:109000
- Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):
- Gu, L., Tian, L., Gao, G., Peng, S., Zhang, J., Wu, D., Huang, J., Hua, Q., Lu, T., Zhong, L., Fu, Z., Pan, X., Qian, H., Sun, L. (2020) Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 266:114664
- Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H.Q., Wu, B. (2020) Single-cell RNA sequencing reveals size-dependent effects of polystyrene microplastics on immune and secretory cell populations from zebrafish intestines. Environmental science & technology. 54(6):3417-3427
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