FIGURE

Fig. 7.

ID

ZDB-FIG-200116-7

Publication

Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

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Fig. 7.

Altered expression of oxidative stress markers in ak2^hg14 embryos. Expression analysis of oxidative stress markers in ak2^hg14 and control sibling (WT) embryos at 4 or 5 dpf. (A) Upregulated expression of several prdx genes in the otic vesicle and PLL at 4 dpf. Bottom panel for prdx1 marker: the black arrows indicate ectopic expression of the marker in PLL neuromasts of the corresponding embryos. (B) Downregulated expression of gpx4a and gpx4b markers at 4 dpf. (C) Specific downregulation of prdx2 marker at 5 dpf in PLL neuromasts and caudal hematopoietic tissue (red arrowhead, CHT). Scale bars: 200 µm. (D) Comparison of gstp1 expression in the PLL neuromasts in control embryos, ak2^hg14 null and ak2^hg16 hypomorphic mutants at 4 dpf. Two different embryos per genotype are shown. Lateral views with anterior to the left. Black arrowheads indicate the otic vesicle. Scale bars: 100 µm.

Expression Data

Genes:	gpx4a gpx4b gstp1.2 prdx1 prdx2 prdx3 prdx4 prdx5 prdx6 (all 9)
Fish:	WT ak2^hg14/hg14 ak2^hg16/hg16
Anatomical Terms:	caudal hematopoietic tissue otic vesicle posterior lateral line posterior lateral line neuromast
Stage Range:	Day 4 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ak2^hg14/hg14 ak2^hg16/hg16
Observed In:	caudal hematopoietic tissue otic vesicle posterior lateral line posterior lateral line neuromast
Stage Range:	Day 4 to Day 5

Phenotype Detail

Acknowledgments

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