Gene

prdx1

ID

ZDB-GENE-050320-35

Name

peroxiredoxin 1

Symbol

prdx1 Nomenclature History

Previous Names

hm:zehl0637
NKEF-A (1)
zgc:110343 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have thioredoxin peroxidase activity. Involved in leukocyte activation. Localizes to protein-containing complex. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Is expressed in several structures, including diencephalon; digestive system; epidermis; lateral line; and neural crest. Orthologous to human PRDX1 (peroxiredoxin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148899 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prdx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
methylmalonic aciduria and homocystinuria type cblC	Alliance	Methylmalonic aciduria and homocystinuria, cblC type, digenic	277400

Associated With prdx1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000866	Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Domain	IPR013766	Thioredoxin domain
Domain	IPR019479	Peroxiredoxin, C-terminal
Family	IPR024706	Peroxiredoxin, AhpC-type
Family	IPR050217	Thiol-specific antioxidant peroxiredoxin
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily

Domain Details Per Protein

Protein	Length	Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant	Peroxiredoxin, AhpC-type	Peroxiredoxin, C-terminal	Thiol-specific antioxidant peroxiredoxin	Thioredoxin domain	Thioredoxin-like superfamily
UniProtKB:A2AWE1 InterPro	199

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prdx1-201 (1) Ensembl	Ensembl	1,224 nt	Select Tool ZFIN BLAST
mRNA	prdx1-202 (1) Ensembl	Ensembl	933 nt	Select Tool ZFIN BLAST
mRNA	prdx1-204 (1) Ensembl	Ensembl	3,160 nt	Select Tool ZFIN BLAST
ncRNA	prdx1-003 (1) Ensembl	Ensembl	627 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB1-prdx1	polyclonal	prdx1		Rabbit			1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations