Gene
prdx1
- ID
- ZDB-GENE-050320-35
- Name
- peroxiredoxin 1
- Symbol
- prdx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable thioredoxin peroxidase activity. Acts upstream of or within leukocyte activation. Part of protein-containing complex. Is expressed in several structures, including diencephalon; digestive system; epidermis; lateral line; and otic vesicle. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148899 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| methylmalonic aciduria and homocystinuria type cblC | Alliance | Methylmalonic aciduria and homocystinuria, cblC type, digenic | 277400 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000866 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| Domain | IPR013766 | Thioredoxin domain |
| Domain | IPR019479 | Peroxiredoxin, C-terminal |
| Family | IPR024706 | Peroxiredoxin, AhpC-type |
| Family | IPR050217 | Thiol-specific antioxidant peroxiredoxin |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant | Peroxiredoxin, AhpC-type | Peroxiredoxin, C-terminal | Thiol-specific antioxidant peroxiredoxin | Thioredoxin domain | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2AWE1 | InterPro | 199 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Bian, L., Nguyen, V.T., Tamaoki, J., Endo, Y., Dong, G., Sato, A., Kobayashi, M. (2023) Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish. Redox Biology. 62:102673102673
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
- Katayama, Y., Saito, A., Ogoshi, M., Tsuneoka, Y., Mukuda, T., Azuma, M., Kusakabe, M., Takei, Y., Tsukada, T. (2022) Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP. Cell and tissue research. 388(2):225-238
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Watanabe, A., Muraki, K., Tamaoki, J., Kobayashi, M. (2022) Soy-Derived Equol Induces Antioxidant Activity in Zebrafish in an Nrf2-Independent Manner. International Journal of Molecular Sciences. 23(9)
- Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:
- Leask, M., Carleton, C., Leeke, B., Newman, T., Antoun, J., Farella, M., Horsfield, J. (2021) Riboceine Rescues Auranofin-Induced Craniofacial Defects in Zebrafish. Antioxidants (Basel, Switzerland). 10(12):
1 - 10 of 64
Show