ZFIN ID: ZDB-GENE-050320-35
Gene Name: peroxiredoxin 1
Gene Symbol: prdx1    Nomenclature History

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Previous Names: hm:zehl0637, zgc:110343 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have thioredoxin peroxidase activity. Involved in leukocyte activation. Localizes to protein-containing complex. Is expressed in several structures, including diencephalon; digestive system; epidermis; lateral line; and neural crest. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1).
Genome Resources: Alliance (1),  Gene:541344 (1),  Ensembl(GRCz11):ENSDARG00000058734 (2)
GENE EXPRESSION
All Expression Data: 19 figures from 10 publications
Directly Submitted Expression Data: 5 figures (7 images) from Thisse et al., 2004 [IMAGE:7148899]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-prdx1
2
MO1-prdx1 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH prdx1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
methylmalonic aciduria and homocystinuria type cblC Alliance Methylmalonic aciduria and homocystinuria, cblC type, digenic 277400
DISEASE ASSOCIATED WITH prdx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process leukocyte activation (more)
Cellular Component protein-containing complex (more)
Molecular Function antioxidant activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA prdx1-201 (1)    Ensembl 1224
prdx1-202 (1)    Ensembl 933
ncRNA prdx1-003 (1)    Ensembl 627
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
AB1-prdx1 polyclonal Rabbit 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM prdx1 No data available
MARKER RELATIONSHIPS
prdx1 Contained in: [BAC] CH73-182A11 (1), CH211-284B7 (1)
prdx1 Encodes: [EST] IMAGE:7148899 (1), zehl0637
[cDNA] MGC:110343 (1), MGC:173697 (1), MGC:192175 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001013471 (1) 1100 nt
Genomic GenBank:AL954171 (1) 148854 nt
Select Tool
Polypeptide UniProtKB:A7MCD6 (1) 201 aa
Sequence Information (all 25)
ORTHOLOGY for prdx1 ( Chr: 2 )
CITATIONS (60)