FIGURE

Fig. 3.

ID

ZDB-FIG-200116-3

Publication

Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

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Fig. 3.

Characterization of PLL neuromast markers in lateral line of ak2^hg14 mutants. (A,B) WISH analysis of atoh1a marker expression in primary and secondary neuromasts on 5 dpf ak2^hg14 (A) and ak2^hg16 (B) embryos and their siblings (WT). (C) eya1 expression from 2.5 to 5 dpf in ak2^hg14 embryos and their siblings. Red arrowheads indicate the primII. Each panel shows higher magnification of the regions in dashed rectangles from corresponding pictures in Fig. S5. Scale bars: 100 µm. (D) Confocal analysis from 2 to 5 dpf of trunk regions of ak2^hg14 embryos and their siblings with different transgenic backgrounds to visualize components of the lateral line rosettes. Scale bars: 50 µm. Yellow arrows indicate pou4f3:GFP⁺ HCs in secondary neuromasts.

Expression Data

Genes:	atoh1a EGFP eya1 GFP Tomato
Fish:	WT ak2^hg14/hg14 ak2^hg16/hg16 s356tTg ak2^hg14/hg14; s356tTg tnks1bp1^y229Gt; nns8Tg ak2^hg14/hg14; tnks1bp1^y229Gt; nns8Tg
Anatomical Terms:	posterior lateral line neuromast posterior lateral line neuromast hair cell
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ak2^hg14/hg14 ak2^hg14/hg14; s356tTg ak2^hg14/hg14; tnks1bp1^y229Gt; nns8Tg
Observed In:	posterior lateral line neuromast
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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