FIGURE

Fig. 4.

ID

ZDB-FIG-200116-4

Publication

Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

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Fig. 4.

Analysis of lateral line phenotypes using different ak2 mutant transgenic lines. (A) Confocal analysis at different developmental stages of the trunk regions of ak2^hg15 embryos and their control siblings (WT) in the Tg(-8.0cldnb:LY-EGFP) background. (B) Confocal analysis from 3.5 to 4 dpf of trunk regions of an ak2^hg15 embryo and a control embryo in the Tg(-8.0cldnb:LY-EGFP) background labeling the migrating secondary primordium (dashed ellipse), deposited secondary neuromast (red circle), connecting interneuromast cells and epithelial cells. Confocal images were collected before and right after the end of the time-lapse confocal movie recording. (C) Confocal analysis from 3 to 5 dpf of trunk regions of ak2^hg14 embryos and their siblings in different lateral line transgenic backgrounds. Yellow asterisks label the interneuromast cells between L1 and L2 in the sqet20Et transgenic line. White and yellow arrowheads denote primI or primII interneuromast cells, respectively. White asterisks label the migrating secondary primordium. Scale bars: 50 µm.

Expression Data

Genes:	EGFP GFP mRFP1
Fish:	sqet20Et zf106Tg ak2^hg14/hg14; sqet20Et ak2^hg15/hg15; zf106Tg sorbs2b^mn0002Gt; s356tTg ak2^hg14/hg14; sorbs2b^mn0002Gt; s356tTg
Anatomical Terms:	posterior lateral line posterior lateral line interneuromast cell posterior lateral line neuromast posterior lateral line neuromast hair cell posterior lateral line neuromast neuromast support cell
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ak2^hg14/hg14; sqet20Et ak2^hg15/hg15; zf106Tg ak2^hg14/hg14; sorbs2b^mn0002Gt; s356tTg
Observed In:	posterior lateral line neuromast posterior lateral line neuromast primordium migration
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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