Gene
prdx3
- ID
- ZDB-GENE-030826-18
- Name
- peroxiredoxin 3
- Symbol
- prdx3 Nomenclature History
- Previous Names
-
- cb718 (1)
- wu:fk49e09
- zgc:110282
- zgc:112512
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable thioredoxin peroxidase activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and musculature system. Used to study autosomal recessive spinocerebellar ataxia 32. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb718 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Naef et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 32 | Alliance | Spinocerebellar ataxia, autosomal recessive 32 | 619862 |
| Corneal dystrophy, punctiform and polychromatic pre-Descemet | 619871 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 32 | AB + CRISPR5-prdx3 | standard conditions | Naef et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000866 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| Domain | IPR013766 | Thioredoxin domain |
| Domain | IPR019479 | Peroxiredoxin, C-terminal |
| Family | IPR050217 | Thiol-specific antioxidant peroxiredoxin |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant | Peroxiredoxin, C-terminal | Thiol-specific antioxidant peroxiredoxin | Thioredoxin domain | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5BJB9 | InterPro | 250 |
Interactions and Pathways
No data available
Plasmids
No data available