ZFIN ID: ZDB-FIG-200116-6
Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress. Disease models & mechanisms   12(12) Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 4

Fig. 6.

Increased cell death in the otic vesicles and the PLL of ak2hg15 embryos. (A) Maximum projections of 3.5 and 4.5 dpf ak2hg15 embryos and their control siblings in the Tg(pou4f3:GAP-GFP) background (indicated as pou4f3) stained with TUNEL assays (red signal). (B,C) Maximum projections (left panels) and representative single plane confocal analysis (right panels) at 4 (B) and 4.5 (C) dpf of a TUNEL assay (red signal) performed on ak2hg15 embryos and their siblings in the Tg(-8.0cldnb:LY-EGFP) background (cldnb, green) labeling the migrating secondary primordium (dashed ellipse), deposited primary and secondary (red circle) neuromasts and epithelial cells. White arrowheads label TUNEL-positive cells in the L1 primary neuromast. Nuclei are labeled with DAPI (blue). Scale bars: 50 µm (A,B); 20 µm (C).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ak2hg15/hg15; s356tTg control Protruding-mouth posterior lateral line neuromast apoptotic process increased occurrence, abnormal
Day 4 posterior lateral line neuromast apoptotic process increased occurrence, abnormal
ak2hg15/hg15; zf106Tg control Day 4 posterior lateral line neuromast apoptotic process increased occurrence, abnormal
Acknowledgments:
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