ZFIN ID: ZDB-FIG-200116-8
Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress. Disease models & mechanisms   12(12) Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage Range: Protruding-mouth to Day 4

Fig. 8.

Antioxidant treatment partially rescues hair cell numbers in the inner ear and the lateral line of ak2hg14 mutants. (A,B) Average number of mature hair cells in the inner ear cristae (top) and anterior macula (bottom) of 3 dpf (A) or in the inner ear cristae of 4 dpf (B) ak2hg14 embryos treated with different concentrations of GSH (100-300 µM). Results are shown as mean±s.e.m. (one-way ANOVA, followed by Tukey's post hoc test; P<0.001). (C) Summary of the percentage of rescue induced by the different GSH treatments on the inner ear cristae and anterior macula at 3 and 4 dpf. (D) Quantitative analysis of the rescue induced by GSH treatments on the expression of alkaline phosphatase in PLL neuromasts of 4 and 5 dpf ak2hg14 and control embryos. Numbers above bars indicate the total amount of embryos used for the analysis. a, anterior; m, medial; p, posterior; UNTR, untreated. A one-way ANOVA (followed by Tukey's post hoc test; P<0.001) was used to compare groups of fish treated differently.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ak2hg14/hg14; s356tTg control Protruding-mouth auditory receptor cell decreased amount, abnormal
Protruding-mouth hair cell anterior macula decreased amount, abnormal
Day 4 auditory receptor cell decreased amount, abnormal
ak2hg14/hg14; s356tTg chemical treatment by environment: glutathione Protruding-mouth auditory receptor cell amount, ameliorated
Protruding-mouth hair cell anterior macula amount, ameliorated
Day 4 auditory receptor cell amount, ameliorated
Acknowledgments:
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