ZFIN ID: ZDB-FIG-191114-27
Bellesso et al., 2018 - FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII). Human molecular genetics   27:2262-2275 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Prim-5 to Long-pec
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Long-pec

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
d2EGFP pt6Tg control Long-pec eye IFL
Long-pec whole organism RTPCR
pt6Tg + MO1-ids standard conditions Long-pec eye IFL
Long-pec whole organism RTPCR
etv4 WT control Long-pec neuromast ISH
Long-pec pectoral fin ISH
WT + MO1-ids standard conditions Long-pec neuromast ISH
Long-pec pectoral fin ISH
pt6Tg control Long-pec whole organism RTPCR
pt6Tg + MO1-ids standard conditions Long-pec whole organism RTPCR
etv5b pt6Tg control Long-pec whole organism RTPCR
pt6Tg + MO1-ids standard conditions Long-pec whole organism RTPCR
fgf3 WT control Prim-5 pharyngeal endoderm ISH
WT + MO1-ids standard conditions Prim-5 pharyngeal endoderm ISH
fgf8a WT control Long-pec diencephalon ventral region ISH
Long-pec telencephalon ISH
WT + MO1-ids standard conditions Long-pec diencephalon ventral region ISH
Long-pec telencephalon ISH
fgfr3 WT control Prim-5 forebrain ventricular zone ISH
WT + MO1-ids standard conditions Prim-5 forebrain ventricular zone ISH
mapk3 pt6Tg control Long-pec whole organism RTPCR
pt6Tg + MO1-ids standard conditions Long-pec whole organism RTPCR
spry4 WT control Prim-5 diencephalon dorsal region ISH
Prim-5 midbrain hindbrain boundary ISH
WT + MO1-ids standard conditions Prim-5 diencephalon dorsal region ISH
Prim-5 midbrain hindbrain boundary ISH
tbxta WT control Prim-5 notochord ISH
WT + MO1-ids standard conditions Prim-5 notochord ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-ids standard conditions Prim-5 diencephalon dorsal region spry4 expression increased amount, abnormal
Prim-5 forebrain ventricular zone fgfr3 expression increased amount, abnormal
Prim-5 midbrain hindbrain boundary spry4 expression increased amount, abnormal
Prim-5 notochord tbxta expression increased amount, abnormal
Prim-5 pharyngeal endoderm fgf3 expression increased amount, abnormal
Long-pec diencephalon ventral region fgf8a expression increased amount, abnormal
Long-pec neuromast etv4 expression increased amount, abnormal
Long-pec pectoral fin etv4 expression increased amount, abnormal
Long-pec telencephalon fgf8a expression increased amount, abnormal
pt6Tg + MO1-ids standard conditions Long-pec whole organism etv4 expression increased amount, abnormal
Long-pec whole organism etv5b expression increased amount, abnormal
Long-pec whole organism mapk3 expression increased amount, abnormal
Long-pec whole organism d2EGFP expression increased amount, abnormal
Full text @ Hum. Mol. Genet.