Gene
spry4
- ID
- ZDB-GENE-010803-2
- Name
- sprouty homolog 4 (Drosophila)
- Symbol
- spry4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Involved in animal organ development and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 53 figures from 42 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb511 (49 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 17 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 17 with or without anosmia | 615266 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sprouty | Sprouty domain-containing protein |
|---|---|---|---|
|
UniProtKB:A0A8M9PQ80
|
310 | ||
|
UniProtKB:Q90XH4
|
310 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids