Gene
spry4
- ID
- ZDB-GENE-010803-2
- Name
- sprouty homolog 4 (Drosophila)
- Symbol
- spry4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including negative regulation of fibroblast growth factor receptor signaling pathway; rhombomere formation; and skeletal muscle fiber development. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 54 figures from 43 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb511 (49 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh117 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la011003Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| spry4_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-spry4 | N/A | Eckfeldt et al., 2005 |
| MO2-spry4 | N/A | Eckfeldt et al., 2005 |
| MO3-spry4 | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 17 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 17 with or without anosmia | 615266 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sprouty | Sprouty domain-containing protein |
|---|---|---|---|
|
UniProtKB:A0A8M9PQ80
|
310 | ||
|
UniProtKB:Q90XH4
|
310 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Sam, J., Torregroza, I., Evans, T. (2024) Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis. Development (Cambridge, England). 151(17):
- Harish, R.K., Gupta, M., Zöller, D., Hartmann, H., Gheisari, A., Machate, A., Hans, S., Brand, M. (2023) Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Development (Cambridge, England). 150(19):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- De Simone, A., Evanitsky, M.N., Hayden, L., Cox, B.D., Wang, J., Tornini, V.A., Ou, J., Chao, A., Poss, K.D., Di Talia, S. (2021) Control of osteoblast regeneration by a train of Erk activity waves. Nature. 590(7844):129-133
- Derrick, C.J., Pollitt, E.J.G., Sevilla Uruchurtu, A.S., Hussein, F., Grierson, A.J., Noël, E.S. (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development (Cambridge, England). 148(20)
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- Kantarci, H., Gou, Y., Riley, B.B. (2020) The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle. eLIFE. 9:
- Bellesso, S., Salvalaio, M., Lualdi, S., Tognon, E., Costa, R., Braghetta, P., Giraudo, C., Stramare, R., Rigon, L., Filocamo, M., Tomanin, R., Moro, E. (2018) FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII). Human molecular genetics. 27:2262-2275
- Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
- Chen, T., Song, G., Yang, H., Mao, L., Cui, Z., Huang, K. (2018) Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish. Genetics. 208(3):1131-1146
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