Gene

spry4

ID
ZDB-GENE-010803-2
Name
sprouty homolog 4 (Drosophila)
Symbol
spry4 Nomenclature History
Previous Names
  • zSpry4 (1)
  • cb511 (1)
  • sprouty4 (1)
  • wu:fb92b06 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Acts upstream of or within animal organ development and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
52 figures from 41 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spry4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 17 with or without anosmia Alliance Hypogonadotropic hypogonadism 17 with or without anosmia 615266
Associated With spry4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007875 Sprouty
Family IPR030790 Protein sprouty homologue 4
Domain Details Per Protein
Protein Length Protein sprouty homologue 4 Sprouty
UniProtKB:F1QZW4 310
UniProtKB:Q90XH4 310
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations