FIGURE

Fig. S3

ID

ZDB-FIG-190722-15

Publication

Zhao et al., 2019 - Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus

Other Figures

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Fig. S3

sas10 is essential for the organogenesis of digestive organs.

(A) Whole-mount in situ hybridization (WISH) using the sas10 probe on WT unfertilized 2 eggs and embryos at 6hpf, 12hpf, and 1dpf to 5dpf. (B) Upper panel: diagram showing the sas10 genomic DNA. Red bar, exons; blue line, introns. Lower panels: showing the DNA sequence changes in sas10Δ8 and sas10Δ2 two mutant alleles which are mutated in the exon4 of the sas10 gene (red letters, deletion; blue letters, insertion; small letters: intron). (C) Representative images showing the overall morphology of a 5dpf-old WT and sas10Δ2 (sΔ2). Black arrow, cardiac region; red arrow, swimming bladder; blue arrow, eye. (D-G) WISH using the prox1 (D) and hhex (E) probes on 30hpf- and 50hpf-old embryos, and the gata6 (F) and foxa3 (G) probes on 30hpf-, 50hpf- and 3dpf-old embryos as shown. The number of total embryos examined (as denominator) and the number of embryos exhibiting the displayed phenotype (as numerator) are shown at the bottom.

Expression Data

Genes:	foxa3 gata6 hhex prox1a utp3
Fish:	AB WT utp3^zju8/zju8
Anatomical Terms:	brain digestive system endoderm liver unfertilized egg whole organism
Stage Range:	1-cell to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	utp3^zju8/zju8
Observed In:	exocrine pancreas development eye heart liver development swim bladder
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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