ZFIN ID: ZDB-GENE-980526-397
Gene Name: prospero homeobox 1a
Gene Symbol: prox1a    Nomenclature History

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Previous Names: prox1 (1), zgc:111888

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity. Involved in several processes, including lymphangiogenesis; negative regulation of DNA-binding transcription factor activity; and neuromast development. Localizes to nucleus. Is expressed in several structures, including digestive system; mesoderm; nervous system; pleuroperitoneal region; and trunk vasculature. Orthologous to human PROX1 (prospero homeobox 1).
Genome Resources: Alliance (1),  Gene:30679 (1),  Ensembl(GRCz11):ENSDARG00000055158 (2)
GENE EXPRESSION
All Expression Data: 164 figures from 99 publications
Directly Submitted Expression Data: 7 figures (26 images) from Thisse et al., 2005 [eu351]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i278 Indel Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
la027849Tg Transgenic Insertion Unknown Unknown DNA
sa23123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23124 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prox1a N/A 10
    MO2-prox1a N/A 1
    MO3-prox1a N/A 2
    DISEASE ASSOCIATED WITH prox1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prox1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of DNA-binding transcription factor activity (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prox1a-201 (1)    Ensembl 3008
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-prox1 polyclonal IgG Goat IHC R&D Systems
    5
    Ab5-prox1 polyclonal IgG Rabbit IHC AngioBio
    18
    Ab7-prox1 polyclonal Rabbit IHC RELIA Tech
    5
    Ab2-Prox1 polyclonal Rabbit IHC 3
    Ab6-prox1 polyclonal Rabbit IHC 7
    Ab3-prox1 polyclonal Rabbit IHC Millipore
    41
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prox1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(prox1a:Citrine) prox1a Citrine Danio rerio 1 4
    TgBAC(prox1a:KALTA4) prox1a KALTA4 Danio rerio 1 3
    TgBAC(prox1a:KALTA4,4xUAS-E1B:TagRFP) E1Bprox1aUAS KALTA4TagRFP Danio rerio 1 24
    MARKER RELATIONSHIPS
    prox1a Contained in: [BAC] DKEY-5J3 (1) (order this)
    prox1a Encodes: [EST] eu351 (1)
    [cDNA] MGC:111888 (1), MGC:191746 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131405 (1) 2839 nt
    Genomic GenBank:BX928753 (1) 73008 nt
    Select Tool
    Polypeptide UniProtKB:F1QAE1 (1) 739 aa
    Sequence Information (all 28)
    ORTHOLOGY for prox1a ( Chr: 17 )
    CITATIONS (191)