ZFIN ID: ZDB-GENE-000622-1
Gene Name: GATA binding protein 6
Gene Symbol: gata6    Nomenclature History

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Previous Names: GATA-5, cb603 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in animal organ development; digestive tract development; and positive regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and congenital heart disease (multiple). Is expressed in several structures, including cardiovascular system; digestive system; endoderm; mesoderm; and yolk syncytial layer. Orthologous to human GATA6 (GATA binding protein 6).
Genome Resources: Alliance (1),  Gene:58076 (1),  Ensembl(GRCz11):ENSDARG00000103589 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38163 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38164 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gata6 N/A 17
    MO2-gata6 N/A 1
    MO3-gata6 N/A 1
    DISEASE ASSOCIATED WITH gata6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 9 Alliance Atrial septal defect 9 614475
    atrioventricular septal defect Alliance Atrioventricular septal defect 5 614474
    double outlet right ventricle Alliance Persistent truncus arteriosus 217095
    tetralogy of Fallot Alliance Tetralogy of Fallot 187500
    Pancreatic agenesis and congenital heart defects 600001
    DISEASE ASSOCIATED WITH gata6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000679 Zinc finger, GATA-type
    Domain IPR008013 GATA-type transcription activator, N-terminal
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Family IPR016375 Transcription factor GATA-4/5/6
    Family IPR039355 Transcription factor GATA
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata6-201 (1)    Ensembl 2054
    gata6-202 (1)    Ensembl 2427
    gata6-203 (1)    Ensembl 1797
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Gt(gata6-EGFP) EGFPgata6 Danio rerio 1 3
    Tg(gata6:GFP) gata6 GFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    gata6 Contained in: [BAC] DKEY-2P18 (1) (order this)
    gata6 Encodes: [EST] cb603 (1) (order this)
    [cDNA] MGC:85943 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131557 (1) 1789 bp
    Genomic GenBank:BX842700 (1) 198258 bp
    Select Tool
    Polypeptide UniProtKB:Q6NW63 (1) 501 aa
    Sequence Information (all 21)
    ORTHOLOGY for gata6 ( Chr: 2 )
    CITATIONS (129)