FIGURE

Fig. 1

ID

ZDB-FIG-190618-33

Publication

Lush et al., 2019 - scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Single cell RNA-Seq reveals support cell heterogeneity.

(A) Et(Gw57a) labels support cells with GFP. (B) Schematic of a cross section through a neuromast. (C) Heatmap showing the expression levels of the top 50 marker genes (y-axis) for each cluster (x-axis), sorted by highest fold change. (D) t-SNE plot showing the different cell clusters. (E) Table of marker genes that distinguish the different cell clusters. (F–Q) t-SNE plots of selected cluster markers and in situ hybridization with these genes. (R, T and U) Schematics of dorsal views of neuromasts with the different cell types colored. (S) Schematic of a cross section through the center of a neuromast.

Expression Data

Genes:	atoh1b dld ebf3a EGFP fndc7rs4 isl1a lfng ovgp1 sfrp1a si:ch73-261i21.5 sost tekt3 wnt11
Fish:	WT sqgw57AEt
Anatomical Terms:	neuromast neuromast hair cell neuromast mantle cell neuromast support cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife