ZFIN ID: ZDB-GENE-980605-16
Gene Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Symbol: lfng    Nomenclature History

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Previous Names: l-fng (1), id:ibd2614 (1), id:ibd5029 (1), id:ibd5138, wu:fc69h02, wu:fi34c01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in fin regeneration; hypochord development; and negative regulation of neuron differentiation. Predicted to localize to integral component of Golgi membrane. Is expressed in several structures, including blastodisc; central nervous system; germ ring; neural plate; and sensory system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase).
Genome Resources: Alliance (1),  Gene:30158 (1),  Ensembl(GRCz11):ENSDARG00000037879 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa721 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11643 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lfng N/A 1
    MO2-lfng N/A 2
    DISEASE ASSOCIATED WITH lfng HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Alliance Spondylocostal dysostosis 3, autosomal recessive 609813
    DISEASE ASSOCIATED WITH lfng VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lfng-201 (1)    Ensembl 2987
    lfng-202 (1)    Ensembl 492
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lfng
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-0.2lfng:EGFP) lfng EGFP Danio rerio 1 5
    Tg(-0.4lfng:EGFP) lfng EGFP Danio rerio 1 5
    Tg(-1.1lfng:EGFP) lfng EGFP Danio rerio 1 5
    MARKER RELATIONSHIPS
    lfng Contained in: [BAC] DKEY-58N10 (1) (order this)
    lfng Encodes: [EST] fc69h02, fi34c01 (1), ibd2614 (1), ibd5029 (1), ibd5138
    [cDNA] MGC:55213 (1), MGC:191948 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130971 (1) 3019 nt
    Genomic GenBank:BX294380 (1) 212685 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B2GQK5 (1) 374 aa
    Sequence Information (all 26)
    ORTHOLOGY for lfng ( Chr: 3 )
    CITATIONS (46)