Gene
sost
- ID
- ZDB-GENE-110411-139
- Name
- sclerostin
- Symbol
- sost Nomenclature History
- Previous Names
-
- si:dkeyp-44b3.1
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant craniodiaphyseal dysplasia | Alliance | Craniodiaphyseal dysplasia, autosomal dominant | 122860 |
| sclerosteosis 1 | Alliance | Sclerosteosis 1 | 269500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine knot, C-terminal | Cystine-knot cytokine | Sclerostin/Sclerostin domain-containing protein 1 |
|---|---|---|---|---|
|
UniProtKB:A0A8M1PZF1
|
210 | |||
|
UniProtKB:E7EXX7
|
210 |
Interactions and Pathways
No data available
Plasmids
No data available