ZFIN ID: ZDB-GENE-110411-139
Gene Name: sclerostin
Gene Symbol: sost    Nomenclature History

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Previous Name: si:dkeyp-44b3.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to localize to extracellular space. Is expressed in Kupffer's vesicle; basibranchial; nervous system; pectoral fin; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
Genome Resources: Alliance (1),  Gene:100000500 (1),  Ensembl(GRCz11):ENSDARG00000061259 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
w215Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
w216Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-sost 1
CRISPR2-sost 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sost HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniometaphyseal dysplasia Alliance Craniodiaphyseal dysplasia, autosomal dominant 122860
sclerosteosis 1 Alliance Sclerosteosis 1 269500
SOST-related sclerosing bone dysplasia Alliance Van Buchem disease 239100
DISEASE ASSOCIATED WITH sost VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of ossification (more)
Cellular Component extracellular region (more)
Molecular Function BMP binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sost-201 (1)    Ensembl 2238
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-sost polyclonal Rabbit IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sost No data available
MARKER RELATIONSHIPS
sost Contained in: [BAC] DKEYP-44B3 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001340647 (1)
Genomic GenBank:CR932037 (1) 151672 nt
Select Tool
Polypeptide UniProtKB:E7EXX7 (1) 210 aa
Sequence Information (all 7)
ORTHOLOGY for sost ( Chr: 12 )
CITATIONS (22)